Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

Multimodal Learning Reveals Genotype–Phenotype Dynamics Background The complex relationship between genotype and phenotype has long been a central question in biology. Genotype refers to the genetic information of an organism, while phenotype is the manifestation of this genetic information in a specific environment. Although Wilhelm Johannsen intr...

Mapping the Gene Space at Single-Cell Resolution: A Study on Gene Signal Pattern Analysis (GSPA) Academic Background Single-cell RNA sequencing (scRNA-seq) technology has made significant progress in biological research in recent years, particularly in revealing the organizational structure of the cellular state space. However, although many comput...

Research Based on Genotype Representation Graph (GRG): A New Framework to Enhance Biobank-Scale Data Analysis Efficiency Academic Background and Research Motivation With the rapid advancement of sequencing technologies, the collection of large-scale genomic data has become increasingly common, especially in the field of human disease association st...

New Advances in Dual-Targeting Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy: Phase 1⁄2 Clinical Trial of Brogidirsen Background Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder primarily affecting skeletal and cardiac muscles, leading to early loss of mobility and, eventually, organ failure. Currently, there is no ...

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...

Revealing Gene Expression Patterns Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy Background Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy, and its pathological features and mechanisms have long drawn extensive attention in the field of neuroscience. This disorder involves not only a single b...

Gene-level Single-cell Trajectory Alignment: A New Method Based on Dynamic Programming The advent of single-cell RNA sequencing (scRNA-seq) technology has dramatically advanced biological research, enabling scientists to observe dynamic changes at the single-cell level over time and space. However, comparing such dynamics across samples or conditio...

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...