Decoding Human Biology and Disease with Single-Cell Omics Technologies Background Introduction Cells are the fundamental units of life. A single fertilized egg can develop into an entire complex human body, composed of approximately 37 trillion cells organized into various tissues, organs, and systems. Traditional cell classification methods primar...
Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Introduction Sepsis, especially severe cases, causes multiple organ dysfunction due to systemic infection, resulting in up to 5 million deaths globally each year. Traditionally, Sepsis-Associated Liver Dysfunction (SALD) was considered a condition accompanied by jaundice ...
Application of Homologous Recombination Deficiency (HRD) in Tumor Patient Assessment and Treatment Planning Background Homologous Recombination (HR) is an important mechanism for repairing DNA Double-Strand Breaks (DSBs). However, when key genes in the HR repair pathway are mutated or epigenetically inactivated, cells are unable to effectively repa...
Omics Perspective on Cell Fate Determination Mechanisms Background Introduction During early mammalian embryo development, a totipotent zygote undergoes several cell divisions and two rounds of cell fate determination, ultimately forming a mature blastocyst. In this process, as the embryo compresses, the establishment of apicobasal cell polarity br...
T2T-YAO: Assembly of a Han Chinese Full-length Diploid Reference Genome Scientific Background Since the launch of the Human Genome Project (HGP) thirty years ago, the field of biomedical research has set a long-term goal of constructing a complete and accurate human reference genome. However, due to limitations in sequencing technology, it has long...
Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...
A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...
The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...
Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...
Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...