Complete Human Recombination Maps Academic Background In genetic research, recombination is one of the key mechanisms by which organisms generate genetic diversity. Recombination not only affects the transmission and combination of genes but also plays a crucial role in natural selection and population history inference. However, existing recombina...

Precise Modeling of Mitochondrial Diseases: Research Based on Optimized Mitobes Academic Background Mitochondrial diseases are a group of genetic disorders caused by mutations in mitochondrial DNA (mtDNA), which affect cellular energy metabolism and lead to dysfunction in multiple organs. Mitochondrial DNA mutations can be homoplasmic (affecting al...

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Leveraging a Phased Pangenome for Haplotype Design of Hybrid Potato Academic Background Potato (Solanum tuberosum L.) is one of the most important tuber crops globally, providing food for over 1.3 billion people annually across more than 120 countries. However, the tetraploid genome and clonal propagation of potatoes result in slow breeding progres...

Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...