Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...
The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...
This article is a biomedical research paper authored by scholars such as Zhang Tingxin, Bi Cheng, and Li Yiran, published on November 6, 2024, in the journal “Neuron.” The research was led by a team from the Tsinghua University-Peking University Center for Life Sciences, exploring the regulatory mechanism of phosphorylation modification of the mech...
Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...
Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...
Disruption of Nucleolar Integrity and Dysregulation of RNA Splicing in C9orf72-FTD/ALS Background and Research Motivation The hexanucleotide repeat expansion (GGGGCC)n in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Studies have shown that these repeat sequences not only...
Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...
Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...
Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...
Integration of Electrophysiological and Genomic Analysis Reveals Tumor Cells Capable of Generating Action Potentials in Human Gliomas Background and Research Objectives Gliomas are the most common malignant tumors in the central nervous system, with approximately 20,000 new cases annually. These tumors include two subtypes: isocitrate dehydrogenase...