Spatial Enrichment and Genomic Analysis Reveal Association between NOMO1 and Amyotrophic Lateral Sclerosis Introduction Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease in which motor neurons in the brain and spinal cord gradually degrade. Although the genetic susceptibility of sporadic ALS patients remains uncertain, TDP-4...

NMDA Receptor Autoantibodies Mainly Damage Extrasynaptic Components Background Information In recent years, neuroimmunology research has revealed various neurological and psychiatric diseases associated with autoantibodies. In these disorders, autoantibodies target various molecules, including receptor membrane proteins, causing abnormal neural sys...

Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...

Using Intracranial EEG-fMRI Mapping of Intermittent Discharges to Predict Epilepsy Surgery Outcomes Background and Objective Epilepsy is a common neurological disorder, and many patients are unresponsive to pharmacological treatments, making surgery one of the primary therapeutic options. However, accurately localizing the seizure onset zone (SOZ) ...

Research Background The core focus of this study is the manifestation of gray matter atrophy in neuroinflammatory diseases. Gray matter atrophy typically appears in four types of neuroinflammatory demyelinating diseases: Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) positive (AQP4+) and negative (AQP4-) for aquaporin-4 an...

In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...

GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...

Dimond: A Study on Optimizing Diffusion Models through Deep Learning Academic Background In brain science and clinical applications, Diffusion Magnetic Resonance Imaging (dMRI) is an essential tool for non-invasively mapping the microstructure and neural connectivity of brain tissue. However, accurately estimating parameters of the diffusion signal...

Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...

Report: Revealing White Matter Changes Associated with Tau in Early Alzheimer’s Disease through Fixel-based Analysis Research Background Alzheimer’s Disease (AD) is generally thought to primarily affect the grey matter (GM), but more and more evidence shows that the white matter (WM) also experiences abnormalities. Current research largely relies o...