Bio-Inspired 3D-Printed Artificial Limb Assisting Cyborg Insects in Self-Righting Locomotion

Bio-Inspired 3D-Printed Artificial Limb Assisting Cyborg Insects in Self-Righting Locomotion

Research Background In rescue missions, to improve search and rescue efficiency, an emerging solution is the use of a combination of electronic backpacks and insects, known as cyborg insects. These insects combine the advantages of biological and electronic technologies, with additional electronic backpacks used for communication, sensing, and cont...

Trimmed Helicoids: An Architectured Soft Structure Yielding Soft Robots with High Precision, Large Workspace, and Compliant Interactions

Trimmed Helicoids: An Architectured Soft Structure Yielding Soft Robots with High Precision, Large Workspace, and Compliant Interactions

Trimming Helicoidal: A Soft Structure with High Precision, Large Workspace, and Compliant Interaction Background Introduction In recent years, inspired by biological systems, many researchers have gradually shifted from traditional rigid robot paradigms towards designs that incorporate compliant materials and structures. An elephant trunk is a typi...

Accelerating Ionizable Lipid Discovery for mRNA Delivery Using Machine Learning and Combinatorial Chemistry

Accelerating the Discovery of Ionizable Lipids for mRNA Delivery using Machine Learning and Combinatorial Chemistry Research Background To fully realize the potential of mRNA therapies, it is essential to expand the toolkit of lipid nanoparticles (LNPs). However, a key bottleneck in LNP development is identifying new ionizable lipids. Previous stud...

Quantum Coherent Spin in Hexagonal Boron Nitride at Ambient Conditions

Report on the Study of Quantum Coherent Spins in Hexagonal Boron Nitride at Room Temperature Introduction The realization of quantum networks and sensors requires solid-state spin-photon interfaces that possess single-photon emission capabilities and long-lived spin coherence, which can be integrated into scalable devices. Ideally, these devices sh...

Elucidating Chirality Transfer in Liquid Crystals of Viruses

Study on Chirality Transfer in Liquid Crystal Viruses Chirality is a phenomenon commonly found in nature and holds significant influence in various fields such as biology, chemistry, physics, and materials science. However, the mechanism of chirality transfer from nanoscale building blocks to macroscopic helical structures remains an unsolved myste...

Distinct Patterns of Plaque and Microglia Glycosylation in Alzheimer’s Disease

Distinct Patterns of Plaque and Microglia Glycosylation in Alzheimer’s Disease

Unique Patterns of Glycosylation in Plaques and Microglia in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is the most common form of dementia and a devastating neurodegenerative disorder. AD is characterized by two pathological features: extracellular β-amyloid (Aβ) plaques and intracellular phosphorylated Tau neurofibrillary ta...

Decreased Microvascular Claudin-5 Levels in Cerebral Amyloid Angiopathy Associated with Intracerebral Haemorrhage

Study on Cerebral Amyloid Angiopathy (CAA) and the Level of Tight Junction Protein Claudin-5 in Microvessels Background Cerebral Amyloid Angiopathy (CAA) is a disease caused by the deposition of Amyloid-β (Aβ) in the cerebral blood vessels. Research indicates that approximately 23% of individuals over the age of 55 have moderate to severe CAA. CAA ...

Sodium Leak Channel in Lateral Parabrachial Nucleus Glutamatergic Neurons Helps Maintain Respiratory Frequency Under Sevoflurane Anesthesia

Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps Maintain Respiratory Rate Under Sevoflurane Anesthesia Background Respiration is a core function for maintaining life activities. General anesthetics and/or opioids often suppress respiratory function. However, the respiratory suppression caused by the intravenou...

Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...

Link Brain-wide Projectome to Neuronal Dynamics in the Mouse Brain

Background Introduction The brain is composed of different subtypes of neurons, which form complex neural networks through local and long-range synaptic connections. Understanding the functions of these neural networks requires knowledge of their connection patterns (projectome) and neuronal dynamics. Although advancements in mesoscale connectomics...