Heart Failure Promotes Multimorbidity through Innate Immune Memory Research Background Despite significant medical advances, the mortality rate of heart failure (HF) remains high, necessitating new therapeutic targets. HF patients often experience acute decompensation and develop comorbidities such as chronic kidney disease and frailty syndrome. Th...

Interaction and Attenuation of Tumor-Specific CD8+ T Cell Responses by LRIG1 and VISTA Academic Background In recent years, the importance of immune checkpoint inhibitors (ICIs) such as Programmed Cell Death Protein 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) has received increasing attention. These inhibitors significantly improve the s...

TREM2 Deficiency Reprograms Gut Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy Background Immune checkpoint inhibitors (CPIs), such as drugs that block programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have been successfully used to activate anti...

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...

The Tumor Lactate-SREBP2 Signaling Pathway Drives Tolerogenic Dendritic Cell Maturation and Promotes Cancer Progression In recent years, the critical role of dendritic cells (DCs) in antitumor immunity has been widely recognized. However, many cancers cause DC dysfunction through mechanisms that are not fully understood. In a newly published study ...

Research Progress in Cancer Immunology: Tumor-derived Antigen Signals Induce CD8+ T-cell Exhaustion Localized to the Tumor Site Research Background and Purpose In recent years, immunotherapy has shown great potential in cancer treatment. However, tracking the behavior of immune cells after receiving antigen signals remains a challenge. Within tumor...

TDRD3 Deficient Mice Exhibit Deficits in Neurogenesis and Synaptic Plasticity at Both Post-transcriptional and Behavioral Levels Research Background Topoisomerase 3b (top3b) is a dual-activity topoisomerase capable of resolving DNA and RNA topological problems. An increasing body of evidence indicates that top3b functions as a conserved complex wit...

A Study on the Effect of YEATS2 Gene Knockdown on Dopaminergic Synaptic Integrity and Epileptic-like Behavior in Drosophila Background Introduction Epilepsy is a common neurological disorder characterized by abnormal electrical activities in the brain. These abnormal activities can lead to seizures and other neurological symptoms. Familial adult my...

One of the key issues in understanding the visual system’s selective attention is how it optimizes the perception and processing of visual information in specific behavioral contexts. Although previous research has analyzed the pivotal role of individual neuron firing rates in information transmission, our understanding remains limited regarding ho...

ABHD6 Drives Endocytosis of AMPA Receptors to Regulate Synaptic Plasticity and Learning Flexibility Research Background In the exploration of the neural system’s mechanisms, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) maintain the tuning ability of neurons in both resting and active states through the regulation of...