Volumetric Microscopy of Cerebral Arteries with a Miniaturized Optical Coherence Tomography Imaging Probe

Volumetric Microscopy of Cerebral Arteries with a Miniaturized Optical Coherence Tomography Imaging Probe

New Breakthrough in the Field of Cerebral Vascular Diseases: Clinical Application of Small Optical Coherence Tomography Imaging Probe Academic Background and Research Motivation In recent years, interventional treatment has become the preferred method for cerebrovascular diseases such as cerebral aneurysm, ischemic stroke, arterial dissection, and ...

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance Through the IL-6/STAT3 Axis

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...

Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients

Encoding of Cerebellar-Olivary Neuronal Ensemble Activity for Tremor Frequency in Mice and Patients with Essential Tremor Research Background Essential Tremor (ET) is a common movement disorder characterized primarily by action tremor, affecting about 20% of the elderly population. The frequency and intensity of tremor are core features of ET. Howe...

Attenuation of Fibroblast Activation and Fibrosis by Adropin in Systemic Sclerosis

Reducing Fibroblast Activation and Fibrosis in Systemic Sclerosis through Adropin Fibrotic diseases of the skin and other organs have become significant socioeconomic challenges in modern society, and current treatment options are limited. This background for this study seeks to address the problem of fibrosis in Systemic Sclerosis (SSc), with the ...

Gain-of-Function Mutations of TRPV4 Acting in Endothelial Cells Drive Blood-CNS Barrier Breakdown and Motor Neuron Degeneration in Mice

This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...

Integrated Analysis of Blood DNA Methylation, Genetic Variants, Circulating Proteins, MicroRNAs, and Kidney Failure in Type 1 Diabetes

Integrated Analysis of Blood DNA Methylation, Genetic Variation, Circulating Proteins, microRNAs, and Kidney Failure in Type 1 Diabetes Research Background Diabetic Kidney Disease (DKD) is one of the major complications of Type 1 Diabetes (T1D). Approximately 40% of T1D patients develop DKD, and 10% to 15% eventually progress to Kidney Failure (KF)...

Mechanism of SRC Inhibition in IDH-Mutant Cholangiocarcinoma

Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...

Closed-loop Optogenetic Neuromodulation Enables High-Fidelity Fatigue-Resistant Muscle Control

Closed-loop Optogenetic Neuromodulation Enables High-Fidelity Fatigue-Resistant Muscle Control

High-Fidelity Fatigue-Resistant Muscle Control Through Closed-Loop Optogenetic Neural Modulation Background Introduction Skeletal muscle is the biological actuator for almost all movements in animals and humans. However, under various neurological conditions, the communication pathways between the central nervous system and neuromuscular components...

Hepatic Danger Signaling Triggers TREM2+ Macrophage Induction and Drives Steatohepatitis via MS4A7-Dependent Inflammasome Activation

Liver Danger Signal Triggers TREM2+ Macrophage-Mediated MS4A7-Dependent Inflammasome Activation Driving Steatohepatitis Background and Research Motivation In recent years, with the increasing incidence of metabolic dysfunction-associated steatohepatitis (MASH), its pathological mechanisms have garnered significant attention. MASH, formerly known as...