Hippo-Yap/Taz Signalling Coordinates Adipose Plasticity and Energy Balance by Uncoupling Leptin Expression from Fat Mass

The Coordinating Role of the Hippo-YAP/TAZ Pathway in Adipose Plasticity and Energy Balance Adipose tissue not only serves as an energy storage depot but also functions as an endocrine organ. However, the mechanisms coordinating these functions remain elusive. This study unveiled that the transcriptional co-regulators YAP and TAZ maintain metabolic...

PNPO-PLP Axis Senses Prolonged Hypoxia in Macrophages by Regulating Lysosomal Activity

Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...

Time of Exercise Differentially Impacts Bone Growth in Mice

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Injectable Ultrasonic Sensor for Wireless Monitoring of Intracranial Signals

Injectable Ultrasonic Sensor for Wireless Monitoring of Intracranial Signals

Wireless Injectable Ultrasound Sensor for Intracranial Signal Monitoring Background Introduction Direct and accurate monitoring of intracranial physiological conditions is extremely important for injury classification, prognosis assessment, and disease prevention. However, traditional wired clinical devices, such as percutaneous leads, although per...

A Novel CNN-Based Image Segmentation Pipeline for Individualized Feline Spinal Cord Stimulation Modeling

Automated Spinal Cord Segmentation Pipeline Based on Convolutional Neural Network (CNN) for Individualized Cat Spinal Cord Stimulation Modeling Background and Research Motivation Spinal cord stimulation (SCS) is a widely used treatment method for chronic pain management. In recent years, it has also been used to modulate neural activity, aiming to ...

Feasibility of Endovascular Stimulation of the Femoral Nerve Using a Stent-Mounted Electrode Array

Feasibility of Intravascular Femoral Nerve Stimulation using a Stent Electrode Array In recent years, electrical stimulation of peripheral nerves has gained attention as a potential therapeutic approach for restoring impaired nerve function. Traditional electrode arrays typically require invasive surgical implantation, which imposes a significant b...

Bayesian Estimation of Group Event-Related Potential Components: Testing a Model for Synthetic and Real Datasets

Background Introduction The study of Event-Related Potentials (ERPs) provides important information about brain mechanisms, particularly in elucidating various psychological processes. In these studies, multi-channel electroencephalograms (EEGs) are typically recorded while subjects perform specific tasks, and the trials are categorized based on st...

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury Traumatic brain injury (TBI) is a serious neurological disorder, and the complexity of its treatment has long plagued the medical community. TBI not only leads to immediate loss of neurological function in patients, but also causes long-term tis...

Neuronal Functional Connectivity is Impaired in a Layer-dependent Manner Near Chronically Implanted Intracortical Microelectrodes in C57BL/6 Wildtype Mice

Layer-Dependent Effects of Chronic Neural Electrode Implants on Neural Functional Connectivity in Mice Introduction This study explores the long-term effects of chronically implanted microelectrodes on neural functional connectivity within the brains of C57BL6 wild-type mice. Implanted intracerebral electrodes enable the recording and electrical st...

Topology of Surface Electromyogram Signals: Hand Gesture Decoding on Riemannian Manifolds

Topology of Surface Electromyography Signals: Decoding Hand Gestures Using Riemannian Manifolds This paper is authored by Harshavardhana T. Gowda (Department of Electrical and Computer Engineering, University of California, Davis) and Lee M. Miller (Center for Mind and Brain Sciences, Department of Neurophysiology and Behavior, Department of Otolar...