This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...

This paper reports an original study on the dynamics of oligodendrocytes in the mouse cortex and white matter using three-photon microscopy. Introduction: Oligodendrocytes are the cells that produce myelin in the central nervous system, which is crucial for neural transmission, cognitive function, and injury repair. Previous studies have shown regi...

Immunotherapy Drives Mesenchymal Transition and Tumor Microenvironment Immune Response in Glioblastoma Introduction Glioblastoma is a highly malignant brain tumor with no curative treatment currently available. Although immunotherapy has shown efficacy in other cancer types, the response in glioblastoma patients is limited. Investigating the effect...

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...

The human genome-encoded triggering receptor expressed on myeloid cells 2 (TREM2) was initially thought to play a role primarily in the central nervous system, participating in the functional regulation of microglia. In recent years, researchers have found that TREM2 is also expressed in peripheral tumors and may promote tumor progression. However,...

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...

Linking microbial evolution and ecological restructuring in the human gut Background: The human gut harbors hundreds of microbial species that interact with each other in a complex ecological network. Recent studies have shown that gut microbes can evolve within human-relevant timescales, but little is known about how this evolution impacts (or is ...