TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...

Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...

Research Report: β-Hydroxybutyrate Improves Redox State, Cytokine Secretion, and Phagocytic Ability of Glucose-Deprived HMC3 Human Microglia Introduction Microglia are resident neuroimmune cells in the brain, accounting for 5-12% of total neuroglial cells, with strong migration, proliferation, and phagocytic abilities. For example, microglia mainta...

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

NARP Laboratory Research Reveals the Impact of SIV Infection on Spinal Cord Gene Expression Background Despite the implementation of antiretroviral therapy (ART), HIV-associated peripheral neuropathy (HIV-DSP) remains one of the most common neurological manifestations of HIV infection. Clinical symptoms of HIV-DSP include weakness, numbness, burnin...

Research Report on the Association between Gene Variants and Neurocognitive Impairment in HIV Patients Over the past few decades, antiretroviral therapy (ART) has greatly improved the health of people infected with human immunodeficiency virus (HIV). However, even with effective viral suppression and partial immune system recovery, up to 50% of Peo...

The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1 Background Ischaemic stroke is the most common type of stroke and a leading cause of death and disability worldwide. Its pathogenesis is complex, involving processes such as oxidative stress...

Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...

Brain-Derived Exosomal Circular RNAs in Plasma as Diagnostic Biomarkers for Acute Ischemic Stroke Acute ischemic stroke (AIS), commonly known as stroke, is a serious condition characterized by interrupted blood flow to the brain, resulting in tissue damage and neurological deficits. Early diagnosis is crucial for effective intervention and manageme...

JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...