Characterization of Extracellular Vesicles from Spinal Cord Tissue in Experimental Autoimmune Encephalomyelitis Introduction Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS), and the etiology and methods for predicting disease progression are still under investigation. Experimental autoimmune encephalom...
Through the Regulation of the TRAF5-MAPK Signaling Pathway in Microglial Polarization, CD36 Inhibits and Alleviates White Matter Damage After Traumatic Brain Injury Research Background Traumatic brain injury (TBI) not only damages gray matter but also causes severe white matter damage. White matter damage results in a significant loss of oligodendr...
The Gender-Dependent Effects of Carbohydrate Sources and Quantity on Caspase-1 Activity in the Central Nervous System of Mice Research Background With the global intensification of aging, the incidence of cognitive impairments and dementia is rapidly increasing, with Alzheimer’s disease being the most common form of senile dementia. Studies have sh...
The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...
Key Research on the Role of Macrophages in Peripheral Nerve Regeneration Background and Research Objectives Since the 1990s, research has shown that macrophages play a promoting role in peripheral nerve regeneration, and are particularly important in the conditioning lesion (CL) response. After sciatic nerve injury, macrophages accumulate at the in...
Protective effects of CCR5-overexpressing mesenchymal stem cells on experimental autoimmune uveitis Background Introduction Uveitis is an inflammatory eye disease that seriously threatens vision and can lead to complications such as cataracts, glaucoma, vitreous opacities, retinal detachment, and abnormal retinal vasculature. This disease is widesp...
Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...
Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...
Neonatal Respiratory Infections Lead to Brainstem Neuroinflammation Introduction Respiratory infections are one of the most common diseases and causes of morbidity among newborns. During the acute phase, infections are known to cause widespread peripheral inflammation. However, the effect of this inflammation on the critical neural centers that con...
Hippocampal Neurons - The Destructive Force Behind Epilepsy and Mental Disorders Background Introduction Tuberous Sclerosis Complex (TSC) is a complex multi-system genetic disorder that manifests with lesions in the brain, skin, heart, kidneys, and other organs as the patient ages. Clinically, TSC presents with symptoms such as epilepsy and develop...