N88S Seipin-related Seipinopathy is a Lipidopathy Associated with Loss of Iron Homeostasis Academic Background Seipin is a protein encoded by the human BSCL2 gene and the yeast SEI1 gene, forming an endoplasmic reticulum (ER)-bound homo-oligomer. This oligomer plays a crucial role in targeting ER-lipid droplet (LD) contact sites, facilitating the d...

PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...

FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance Background Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths. Although surgical resection and adjuvant chemotherapy are the primary treatments for CRC, tumor development and chemot...

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...

The Critical Role of Kindlin-3 in β2 Integrin Clustering Academic Background Neutrophils are the most abundant type of white blood cells in human blood, and their recruitment is essential for innate immunity and inflammatory responses. The initial and critical step in neutrophil recruitment is their adhesion to vascular endothelial cells, which dep...

The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...

PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells Academic Background Breast Cancer Stem Cells (BCSCs) are a rare subpopulation of cells within breast cancer that possess the ability to self-renew, initiate tumors, and metastasize. Despite their critical role in tumor initiation and progression, the mec...

Mitochondrial Unfolded Protein Response-Dependent β-Catenin Signaling Promotes Neuroendocrine Prostate Cancer Academic Background Prostate cancer is the second most commonly diagnosed cancer in American men, second only to skin cancer. Although current treatments, such as androgen deprivation therapy (ADT), can induce remission in prostate cancer, ...

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...