PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

GCN2-SLC7A11 Axis Coordinates Autophagy, Cell Cycle, and Apoptosis and Regulates Cell Growth in Retinoblastoma upon Arginine Deprivation

GCN2-SLC7A11 Axis Regulates Cell Growth and Survival in Retinoblastoma Under Arginine Deprivation Background Retinoblastoma (RB) is a common intraocular malignant tumor in children, accounting for 4% of all childhood cancers. Although current treatments such as chemotherapy are effective in some patients, they have drawbacks such as multidrug resis...

Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities

The Impact of Nanotopography on Cellular Metabolic Activities: Multimodal Imaging Reveals New Insights Academic Background In the field of biomedicine, the interaction between cells and material surfaces is crucial for studying cell behavior, tissue engineering, and regenerative medicine. Nanoscale surface topography (nanotopography) has been shown...

Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers

Applications of Volumetric Additive Manufacturing in Cell Printing Academic Background Volumetric Additive Manufacturing (VAM) is a revolutionary 3D printing technology capable of rapidly creating complex three-dimensional structures, particularly in the field of cell printing. VAM can mimic the structures of natural tissues, offering new possibili...

Self-Assembled DNA−Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation

Self-Assembled DNA-Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation Academic Background In molecular biology research, the interaction between DNA and proteins has always been a crucial topic for understanding cellular processes. With the deepening understanding of DNA-protein interactions, this knowledge has been w...

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Tryptophan 2,3-Dioxygenase-Positive Matrix Fibroblasts Fuel Breast Cancer Lung Metastasis via Kynurenine-Mediated Ferroptosis Resistance of Metastatic Cells and T Cell Dysfunction

Mechanism of Stromal Fibroblasts in Breast Cancer Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and metastasis is the leading cause of death in breast cancer patients. The lung is one of the most common sites of breast cancer metastasis, yet the mechanisms underlying this process rema...

Phosphorylation of BOK at Ser-8 Blocks Its Ability to Suppress IP3R-Mediated Calcium Mobilization

The New Role of BOK Protein in Calcium Signaling Regulation Background Introduction BOK (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family and has long been thought to play a role in cell apoptosis. However, recent studies suggest that BOK may also have non-apoptotic functions, particularly in the regulation of calcium ion (Ca²⁺...

The SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction

SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...

Signal Integrator Function of CXXC5 in Cancer

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...