Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...

Research on Alleviating Gastrointestinal Inflammation by Adjusting Intestinal Circadian Rhythm through Feeding Time Background Information Impaired expression of intestinal circadian rhythm genes has been observed in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, such as that occurring in shift worker...

Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...

Academic Background and Research Question In antiviral efficacy research, type I interferon (IFN-I) has been widely used clinically due to its broad-spectrum antiviral properties. However, the specific signaling mechanism and regulatory modes of IFN-I remain complex and not fully elucidated. In light of this, experts have begun to pay attention to ...

Study on IRF1 Transcriptional Activation Regulation of Radiation-Induced Cell Death and Inflammatory Response under Mutagenic Stress Background Recent multi-omics studies have revealed the key role of structural cells in immune regulation, but the mechanism remains unclear. Based on this, this study mainly explores how the transcriptional activatio...

Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...

This report is based on the following research article: “neutrophil–macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome”, written by Haixia Kang, Ting Liu, Yuanyuan Wang, Wenjuan Bai, Yan Luo, and Jing Wang, published in the journal “Cellular & Molecular Immunology” in ...

Spatiotemporal Regulation of KLF2 and T-bet by Eomesodermin During NK Cell Development I. Research Background Natural Killer (NK) cells are important cells in the immune system, capable of recognizing and killing tumor cells and pathogen-infected cells. The generation and development of NK cells depend on the gradual acquisition of a series of spec...

Targeting STING in Dendritic Cells Alleviates Psoriatic Inflammation Psoriasis is a common chronic inflammatory skin disease primarily caused by abnormal activation of dendritic cells (DCs) and T cells, ultimately leading to increased cytokines such as interleukin (IL)-23 and IL-17A. The cGAS-STING pathway is known to play a key role in psoriatic i...