Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...

Research Report on the Effects of Naringin Intervention on Newborn Neurons and BDNF Levels in Rat Brain Ischemia-Reperfusion Model Background With the global increase in cardiovascular diseases, ischemic stroke has gradually become a major cause of death and disability, affecting the quality of life of millions of people. Despite continuous advance...

Differential Regulation of miR206 and miR423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis Patients This article was published in the 2024 issue of “Neuromolecular Medicine,” titled “Differential Regulation of miR206 and 423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis (ALS) Patients.” The authors include ...

Research Background This study explores the role of the cancer-related transcription factor c-myc in penumbra neurons following ischemic stroke. Although the role of c-myc in cell death and survival has been recognized, research on its post-translational modifications, especially acetylation, in ischemic models remains insufficient. Investigating t...

Inhibition of p70 ribosomal S6 kinase (S6K1) Reduces Cerebral Cortical Blood Flow in Autism-Tuberous Sclerosis Rats: Research Report Background Tuberous Sclerosis Complex (TSC) is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, primarily characterized by multiple benign tumors, including symptoms such as epilepsy, autism spectrum ...

Preliminary Research Report on the Relationship between CYP46A1 Polymorphism and Suicide Risk Research Background Suicide, defined as the intentional act of ending one’s own life, is a major global public health issue. The incidence of suicide is higher among individuals with Major Depressive Disorder (MDD). However, the role of cholesterol in suic...

Mechanism Study of Circular RNA-GRIN2B Inhibiting Neuropathic Pain Background Introduction Neuropathic pain is a persistent pain caused by damage to the somatic sensory nervous system, with its etiology not yet fully understood and clinical treatment facing many difficulties. Given the complexity of neuropathic pain, there is an urgent need to reve...

Scientific Research Report: Drug Treatment Alleviates Retinal Ganglion Cell Death in Normal Tension Glaucoma Mouse Model by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation Background Normal Tension Glaucoma (NTG) is a progressive neurodegenerative disease in the glaucoma family. Typically, glaucoma is associated with elevated intra...

Long-term Effects of CD8+ T Cell Subsets in Neuroinflammation After Ischemic Stroke Background Ischemic stroke is a leading cause of death and disability. After stroke, neuroinflammation is rapidly induced, activating various cells such as mast cells, astrocytes, microglia, and vascular endothelial cells. These reactive cells then express various i...

Effects of Clemizole on Parkinson’s Disease Pathology Induced by α-Synuclein Fibril Formation Background Introduction Parkinson’s Disease (PD) is a typical neurodegenerative disease, mainly associated with mitochondrial dysfunction and oxidative stress. However, current therapeutic approaches targeting these pathological events have not successfull...