Dimensionality reduction beyond neural subspaces with slice tensor component analysis

Information Science, Artificial Intelligence, Life Sciences, Biochemistry, Genetics, Biophysics,
neural activity   tensor decomposition   covariability classes  

Background Introduction: Large-scale neural recording data can typically be described by patterns of co-activated neurons. However, the view of constraining neural activity variability to a fixed low-dimensional subspace may overlook higher-dimensional structures, such as fixed neural sequences or slowly evolving latent spaces. This study argues th...

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the contribution of the chemical exposome to neurodegenerative disease

Chemistry, Analytical Chemistry, Environmental Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
neurodegenerative diseases   exposome   chemicals   Alzheimer's disease   Parkinson's disease  

Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...

Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
splicing isoforms   splicing regulation   development   regions   cell types  

Single-cell sequencing technology reveals unique splicing patterns in developing and adult mouse and human brains In the nervous system, the splicing patterns of messenger RNA (mRNA) play a critical role in establishing cellular identity and regulating cellular functions. However, a comprehensive atlas depicting the mRNA splicing patterns across br...

Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
neurodevelopment   gene expression   autism   schizophrenia   neuroimaging  

Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
messenger RNA   lysosomal vesicles   axonal mitochondria   neurodegeneration   RNA granules  

This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...

The transcription factor Meis2 promotes the development of projection neurons during mouse embryonic development by binding to and activating projection neuron-specific enhancers with Dlx5

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
transcription factor   Meis2   Dlx5   enhancers   projection neurons  

This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...