ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...

SMARCA4 is a Haploinsufficient B Cell Lymphoma Tumor Suppressor that Fine-Tunes Centrocyte Cell Fate Decisions

Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...

Dendritic-Cell-Targeting Virus-Like Particles as Potent mRNA Vaccine Carriers

Dendritic-cell-targeting Virus-like Particles as Potent mRNA Vaccine Carriers Introduction In vaccine development, especially mRNA vaccines, significant achievements have been made in recent years. The mRNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19 have set a successful precedent, greatly advancing the development of mRNA v...

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

The Application of Antibodies Displaying Extracellular Vesicles in Targeted Cancer Therapy Extracellular Vesicles (EVs) have been extensively researched as natural delivery carriers and mediators of biological signals in various tissues. In this study, researchers utilized these characteristics of EVs to demonstrate a modular delivery system for ca...

Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing

Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing

Spatial Multi-omics High Throughput In Situ Pairwise Sequencing at Subcellular Resolution Research Background and Objectives With the continuous advancement in biomedical research, the application of multi-omics technologies in understanding cell functions and disease mechanisms has gained increasing attention. However, many current in situ sequenc...

Precision Colorectal Cancer Screening with Fecal Hemoglobin Concentration-Guided Intervals

Precise Colorectal Cancer Screening Based on Customized Intervals Using Fecal Hemoglobin Concentration Researchers: Amy Ming-Fang Yen, Yang-Ching Chen, Yu-Lin Ding, Wen-Zhu Qiu, Han-Mo Qiu, Tony Hsiu-Hsi Chen, Sam Li-Sheng Chen Academic Background Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. In recent years, significant...

Accelerating Diabetic Wound Healing by ROS-Scavenging Lipid Nanoparticle–mRNA Formulation

Accelerating Diabetic Wound Healing by ROS-Scavenging Lipid Nanoparticle–mRNA Formulation

Utilization of Lipid Nanoparticles-mRNA Formulations to Eliminate ROS and Accelerate Diabetic Wound Healing Diabetic wounds are common complications in patients with hyperglycemia, characterized by high incidence and recurrence rates, causing substantial global economic losses. Existing treatments, including wound offloading and growth factor thera...

Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics

Differences in Coupling Between Cortical Networks Related to Arousal in Neural Activity and Hemodynamics Academic Background In the absence of specific sensory inputs or behavioral tasks, the brain generates structured activity patterns. This organized activity is modulated by the state of arousal. The relationship between arousal and cortical acti...

Dopamine and Serotonin in Human Substantia Nigra Track Social Context and Value Signals During Economic Exchange

Dopamine and Serotonin in Human Substantia Nigra Track Social Context and Value Signals During Economic Exchange

Background Introduction In contemporary neuroscience research, dopamine and serotonin are hypothesized to be crucial neuromodulators guiding social behavior. However, there is a significant lack of understanding regarding the dynamic changes of these neuromodulators during social interactions. Although non-invasive functional neuroimaging methods (...