Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...

Mechanism of SRC Inhibition in IDH-Mutant Cholangiocarcinoma

Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...

Phasic/Tonic Glial GABA Differentially Transduce for Olfactory Adaptation and Neuronal Aging

Phasic/Tonic Glial GABA Differentially Transduce for Olfactory Adaptation and Neuronal Aging

Background Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, regulating neuronal activity and plasticity through two distinct modes: phasic and tonic. However, our understanding of the mechanisms and physiological functions of GABA transmission in glial cells remains limited. Glial cells, especially astrocytes, ca...

Human Cortical Neurogenesis is Altered via Glucocorticoid-Mediated Regulation of ZBTB16 Expression

Human Cortical Neurogenesis is Altered via Glucocorticoid-Mediated Regulation of ZBTB16 Expression

Glucocorticoids Alter Human Cortical Neurogenesis by Regulating ZBTB16 Expression Background Introduction During pregnancy, glucocorticoids (GCs) are crucial steroid hormones for the development of the central nervous system (CNS). GCs regulate the development of fetal organs, particularly the lungs and brain. However, when GC levels exceed the phy...

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

Astrocytes Secrete Neurocan to Control Inhibitory Synapse Formation and Function In recent years, the role of neuron-glial cell interactions in synapse formation and maintenance of synaptic function has become a hot topic in neuroscience research. This paper, published by Dolores Irala et al. from Duke University Medical Center in the May 2024 issu...

p-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...

Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers

Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...

Molecular Targets of Glucocorticoids that Elucidate Their Therapeutic Efficacy in Aggressive Lymphomas

Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells Academic Background Checkpoint inhibitors (CPIs) have revolutionized cancer treatment by blocking immune regulatory signals mediated by checkpoint molecules, restoring T cell-mediated tumor clearance. However, these therapies also lead to a range of immune-related adverse events (IRAEs), wi...

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...