NMDA Receptor Autoantibodies Mainly Damage Extrasynaptic Components Background Information In recent years, neuroimmunology research has revealed various neurological and psychiatric diseases associated with autoantibodies. In these disorders, autoantibodies target various molecules, including receptor membrane proteins, causing abnormal neural sys...

GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...

Report: Revealing White Matter Changes Associated with Tau in Early Alzheimer’s Disease through Fixel-based Analysis Research Background Alzheimer’s Disease (AD) is generally thought to primarily affect the grey matter (GM), but more and more evidence shows that the white matter (WM) also experiences abnormalities. Current research largely relies o...

The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...

Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...

This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...

Background Introduction: Large-scale neural recording data can typically be described by patterns of co-activated neurons. However, the view of constraining neural activity variability to a fixed low-dimensional subspace may overlook higher-dimensional structures, such as fixed neural sequences or slowly evolving latent spaces. This study argues th...

Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...

Single-cell sequencing technology reveals unique splicing patterns in developing and adult mouse and human brains In the nervous system, the splicing patterns of messenger RNA (mRNA) play a critical role in establishing cellular identity and regulating cellular functions. However, a comprehensive atlas depicting the mRNA splicing patterns across br...

Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...