Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
messenger RNA   lysosomal vesicles   axonal mitochondria   neurodegeneration   RNA granules  

This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...

The transcription factor Meis2 promotes the development of projection neurons during mouse embryonic development by binding to and activating projection neuron-specific enhancers with Dlx5

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
transcription factor   Meis2   Dlx5   enhancers   projection neurons  

This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...