This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...
Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...
Childhood Gliomatosis Cerebri: A Poor Prognosis Phenotype of Diffuse Glioma with Distinct Molecular Characteristics Introduction Gliomatosis cerebri (GC) is a highly invasive form of diffuse glioma. It was initially discarded as an independent pathological type due to its indeterminate molecular characteristics. However, with the advancements in mo...
Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...
Systematic Analysis of NDUFAF6 in Complex I Assembly and Mitochondrial Disease Background Mitochondrial complex I (CI) is a crucial component of the respiratory chain, playing an essential role in oxidative phosphorylation (OXPHOS) by introducing electrons into the mitochondrial respiratory chain and, together with complexes II-IV, generating and m...
Nucleotide Adduct Binding MR1 and Activation of MR1-Restricted T Cells Academic Background MR1T cells, a recently discovered class of T cells, can recognize antigens presented by MHC class I-related molecule MR1 without microbial infection. These cells exhibit both helper and cytotoxic properties in vitro, but the endogenous antigens they recognize...
TREM2 Deficiency Reprograms Gut Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy Background Immune checkpoint inhibitors (CPIs), such as drugs that block programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have been successfully used to activate anti...
TDRD3 Deficient Mice Exhibit Deficits in Neurogenesis and Synaptic Plasticity at Both Post-transcriptional and Behavioral Levels Research Background Topoisomerase 3b (top3b) is a dual-activity topoisomerase capable of resolving DNA and RNA topological problems. An increasing body of evidence indicates that top3b functions as a conserved complex wit...
A Study on the Effect of YEATS2 Gene Knockdown on Dopaminergic Synaptic Integrity and Epileptic-like Behavior in Drosophila Background Introduction Epilepsy is a common neurological disorder characterized by abnormal electrical activities in the brain. These abnormal activities can lead to seizures and other neurological symptoms. Familial adult my...
A Panoramic View of Whole Genome Repetitive Sequences in Cancer and Circulating Free DNA Research Background and Significance Throughout the development of cancer and other diseases, genetic changes in repetitive sequences within the genome are a significant characteristic. However, standard sequencing methods struggle to effectively characterize t...