Spatial Enrichment and Genomic Analysis Reveal Association between NOMO1 and Amyotrophic Lateral Sclerosis Introduction Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease in which motor neurons in the brain and spinal cord gradually degrade. Although the genetic susceptibility of sporadic ALS patients remains uncertain, TDP-4...
In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...
Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...
Background Myelodysplastic Syndromes (MDS) are a group of heterogeneous diseases originating from bone marrow hematopoietic stem cells, characterized by reduced blood cell production. Although certain progress in treatment has been made in recent years, allogeneic hematopoietic stem-cell transplantation (HSCT) remains the only potentially curative ...
Study on the Extent of Resection Threshold in Different Molecular Subtypes of Newly Diagnosed IDH-wildtype Glioblastoma Introduction Glioblastoma (GBM) is the most common malignant brain tumor in adults. Although surgical resection, radiotherapy, and chemotherapy are the current standard treatment regimens, the prognosis of GBM remains poor, with a...
The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...
This paper reports on research investigating how zebra finches recover their complex learned behaviors following large-scale neuronal perturbations. The researchers selectively disrupted the activity of the projection neurons in the HVC (hyperpallium ventralis) region critical for song sequence generation in zebra finches using genetic tools, leadi...
This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...
Background Introduction: Large-scale neural recording data can typically be described by patterns of co-activated neurons. However, the view of constraining neural activity variability to a fixed low-dimensional subspace may overlook higher-dimensional structures, such as fixed neural sequences or slowly evolving latent spaces. This study argues th...
Single-cell sequencing technology reveals unique splicing patterns in developing and adult mouse and human brains In the nervous system, the splicing patterns of messenger RNA (mRNA) play a critical role in establishing cellular identity and regulating cellular functions. However, a comprehensive atlas depicting the mRNA splicing patterns across br...