Using Genome Synteny Analysis for Strain Tracking in Complex Microbiomes Reveals Species-Specific Evolutionary Patterns Background Microbial populations differentiate into distinct strains through single-nucleotide mutations and structural variations such as recombination, insertions, and deletions. Most strain comparison methods primarily quantify...

Single-Sample Tumor Subclonal Reconstruction Algorithm Based on Crowd-Sourced Resources Background The evolution of cancer and the genetic heterogeneity of tumors are critical fields in modern oncology research. Tumors evolve from normal cells through progressive acquisition of somatic mutations. These mutations occur probabilistically, influenced ...

Multiple Prior Knowledge Graph Neural Network in Multi-Omics Data Analysis Background Introduction Precision medicine is an important field for the future of healthcare as it provides personalized treatment plans for patients, improving treatment outcomes and reducing costs. For instance, due to the complex clinical, pathological, and molecular cha...

This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...

Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...

Childhood Gliomatosis Cerebri: A Poor Prognosis Phenotype of Diffuse Glioma with Distinct Molecular Characteristics Introduction Gliomatosis cerebri (GC) is a highly invasive form of diffuse glioma. It was initially discarded as an independent pathological type due to its indeterminate molecular characteristics. However, with the advancements in mo...

Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...

Systematic Analysis of NDUFAF6 in Complex I Assembly and Mitochondrial Disease Background Mitochondrial complex I (CI) is a crucial component of the respiratory chain, playing an essential role in oxidative phosphorylation (OXPHOS) by introducing electrons into the mitochondrial respiratory chain and, together with complexes II-IV, generating and m...

Nucleotide Adduct Binding MR1 and Activation of MR1-Restricted T Cells Academic Background MR1T cells, a recently discovered class of T cells, can recognize antigens presented by MHC class I-related molecule MR1 without microbial infection. These cells exhibit both helper and cytotoxic properties in vitro, but the endogenous antigens they recognize...

TREM2 Deficiency Reprograms Gut Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy Background Immune checkpoint inhibitors (CPIs), such as drugs that block programmed cell death protein-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have been successfully used to activate anti...