How to Reduce the Expectations and Demand for Antibiotics in the Face of the Threat of a “Post-Antibiotic Era” Introduction Antibiotic resistance is becoming a global public health threat. Although the evolution of this resistance is a biological process, human behavior, especially unnecessary antibiotic use in agricultural production and human med...
In the global context, the prevalence of obesity is on the rise, bringing significant impacts to public health. Obesity is independently associated with the incidence and mortality of cardiovascular diseases, with an estimated economic burden exceeding $200 billion annually for healthcare systems. In recent years, glucagon-like peptide-1 (GLP-1) re...
The Mediating Role of Systemic Inflammation in the Differences in Cognitive Disease Incidence and the Moderating Role of Racialization This study examines the link between systemic racism and the increased burden of cognitive disease. Researchers investigated the mediating role of C-reactive protein (CRP) as a marker of systemic inflammation in the...
In the global context, the Planetary Health Diet has been proposed as a way to improve human health while protecting the Earth. However, studies on the relationship between the Planetary Health Diet and cognitive decline are very limited. To fill this research gap, researchers Natalia Gomes Gonçalves, Leandro Teixeira Cacau, Naomi Vidal Ferreira, P...
Clinical Aging Clock Based on Principal Components Reveals Characteristics of Healthy Aging and Targets for Clinical Interventions Background of the Study As the population ages, promoting healthy aging and slowing down biological aging has become an important issue. To accurately predict all-cause mortality and obtain feasible measures to promote ...
A Large Prospective Cohort Study in the United States Reveals Potential Links Between Outdoor Air Pollution and Subtypes of Adult Hematologic Cancers Background and Purpose In recent years, the impact of outdoor air pollution on human health has garnered extensive attention. Since 2013, the International Agency for Research on Cancer (IARC) has cla...
The Epitranscriptomic Landscape of N6-Methyladenosine Modification in Lung Adenocarcinoma Background Lung cancer is one of the most common cancers globally and a leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 80%-85% of all lung cancer cases, among which lung adenocarcinoma (LUAD) is of particular conc...
Study on the Impact of Poverty on Mental Illness: A Mendelian Randomization Analysis Based on the UK Biobank This article aims to explore the causal relationship between poverty and mental illness. Although many studies have shown an association between low socioeconomic status and mental illnesses, most studies have failed to determine whether pov...
Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...
Study on the Genetic and Environmental Effects of Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence I. Background and Significance Adverse childhood events (ACE) often have profound effects on an individual’s mental health and substance dependence. Previous studies have shown a close relationship between ACE and mood an...