GYS1 Antisense Therapy Inhibits Pathogenic Aggregates and Epileptiform Discharges in a Mouse Model of Lafora Disease Background and Objectives Lafora disease (LD) is a devastating autosomal recessive genetic disorder characterized by epilepsy and rapidly progressive dementia in adolescence. The disease primarily involves mutations in the EPM2A or E...
D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...
Gut Microbiota-Derived Indole-3-Acetic Acid (3-IAA) Suppresses High Myopia Progression by Promoting Type I Collagen Synthesis Background High myopia (HM) is a serious vision-threatening ocular condition associated with complications such as glaucoma, cataracts, and macular degeneration. Currently, effective interventions for high myopia are lacking...
Developing a Novel Erythrocyte-MHC-I Conjugate for Cancer Treatment: A Revolutionary Immunotherapy Research Background: Traditional Roles and Newly Discovered Potential Erythrocytes, or red blood cells, are the most abundant cells in the human body, comprising approximately 70% of total cell count in adults. Traditionally recognized for their role ...
Crossing the Blood–Brain Barrier: Study on Adipose-Derived Stem Cells as Carriers for Pro-Apoptotic Oncolytic Myxoma Virus in the Treatment of Murine Glioblastoma Background and Objective Glioblastoma (GBM) is among the most invasive and aggressive brain tumors, characterized by high recurrence rates and poor prognosis. Despite multimodal intervent...
Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness, Increasing Anti-PD-1 Therapy Responsiveness in Glioblastoma Background and Objectives of the Study Glioblastoma (GBM) is an aggressive central nervous system tumor with poor prognosis, and the median survival of patients is only 14.6 months. Despite the significant efficacy of immune ch...
Cotton Population-Level DNA Methylation Polymorphism Study Reveals Epigenomic Contributions to Complex Traits Background and Research Motivation In recent decades, genome and genetic diversity have been extensively studied through genome-wide association studies (GWAS), providing a theoretical foundation for understanding crop trait variations. How...
New Discovery in Metabolic Regulation of Muscle Stem Cell Activation: The Crucial Role of the Spermidine-eIF5A Axis Background and Research Objectives Adult skeletal muscle satellite cells (SCs) are the main type of stem cells in skeletal muscle and play a pivotal role in muscle injury repair. However, the activation mechanism of quiescent satellit...
Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...
Deep Learning-Driven Protein Design: Generating Functional Protein Sequences Using Conditional Diffusion Models Proteins are at the core of life sciences research and applications, offering countless possibilities due to their diversity and functional complexity. With advancements in deep learning technologies, protein design has reached a new pinn...