PNPO-PLP Axis Senses Prolonged Hypoxia in Macrophages by Regulating Lysosomal Activity
Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...