Background Introduction Cancer of Unknown Primary (CUP) is a type of malignant disease that is confirmed to be metastatic through histopathology but whose primary site cannot be identified using conventional baseline diagnostic methods. CUP presents significant diagnostic and therapeutic challenges in clinical practice and is believed to account fo...
The Effectiveness of Bivalent CAR T-Cell Therapy Targeting EGFR and IL13Rα2 in Treating Recurrent Glioblastoma In recent years, the treatment of recurrent glioblastoma (RGBM) has been continually explored and improved, yet overall survival rates remain less than one year, presenting a significant challenge. The limitations of existing treatments an...
GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...
Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...
This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...
The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...
Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...
This paper reports on research investigating how zebra finches recover their complex learned behaviors following large-scale neuronal perturbations. The researchers selectively disrupted the activity of the projection neurons in the HVC (hyperpallium ventralis) region critical for song sequence generation in zebra finches using genetic tools, leadi...
This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...
I. Research Background and Purpose The subcommissural organ (SCO) is a glandular structure located at the entrance of the ventricular system, which is present in humans and other vertebrates, but its function has not been fully elucidated. Previous studies have suggested that the SCO may be involved in the regulation of neural development and the m...