Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...

TREM2 mediates MHC II-associated CD4+ T-cell response against gliomas

The human genome-encoded triggering receptor expressed on myeloid cells 2 (TREM2) was initially thought to play a role primarily in the central nervous system, participating in the functional regulation of microglia. In recent years, researchers have found that TREM2 is also expressed in peripheral tumors and may promote tumor progression. However,...

NF1 mutation-induced neuronal hyperexcitability drives murine optic glioma growth and can be targeted by lamotrigine treatment

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...