Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...
In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...
Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...
Research Report: Dominance and Persistence of T-Cell Clones in Tumor-Infiltrating Lymphocytes during Expansion in Breast Cancer Background Tumor-infiltrating lymphocytes (TILs) are lymphocytes that naturally infiltrate the tumor microenvironment and exhibit reactivity to the tumor. This subject is one of the most actively researched areas in tumor ...
Context-Aware Network Study Report for Glioma Segmentation Glioma is a common type of adult brain tumor that severely harms health and has a high mortality rate. To provide sufficient evidence for early diagnosis, surgical planning, and postoperative observation, multimodal Magnetic Resonance Imaging (MRI) has been widely applied in this field. The...
Comparison of Acoustic Patterns and Microbubble Delivery Strategies in Large-Volume Drug Delivery Mediated by Focused Ultrasound for Blood-Brain Barrier Opening Background Diffuse Intrinsic Pontine Glioma (DIPG) is the most common and lethal brainstem tumor in children. Due to the usually intact blood-brain barrier (BBB) in DIPG, drug penetration i...
Application of Lifileucel in Advanced Non-Small Cell Lung Cancer Patients Resistant to Immune Checkpoint Inhibitors This article, authored by Adam J. Schoenfeld and numerous other top scholars, was published in the 2024 edition of Cancer Discovery. The study is based on a multi-center phase II clinical trial aiming to evaluate the efficacy and safe...
St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...
Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...
In the current field of tumor treatment, precision medicine continues to be a research hotspot and development trend. With the advancement of science and technology, we have begun to more accurately understand the characteristics of tumor cells and their dependencies for survival, in hopes of finding new therapeutic targets. Particularly, strategie...