Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study

Research Report: Predictive Role of Cerebrospinal Fluid Routine Parameters in the Disease Process of Multiple Sclerosis Background Multiple Sclerosis (MS) is characterized by a highly variable and unpredictable disease course. In the diagnosis of MS, cerebrospinal fluid (CSF) analysis is often a standard procedure. However, there has been ongoing d...

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits CGAS-mediated anticancer immunity

This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...

Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy

Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy

This study utilized a machine learning framework to explore the underlying cell states and cellular ecosystems constituting soft tissue sarcomas, and associated them with patient prognosis and response to immunotherapy. Research Background: Soft tissue sarcomas are rare and highly heterogeneous malignancies of connective tissues, with limited syste...

Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

In this study, researchers explored the role of the TAK1 activation pathway in CAR T cell therapy-associated immune effector cell-associated neurotoxicity syndrome (ICANS). They established a mouse ICANS model and found that following the transfer of CAR19 T cells, cerebellar cells were activated, underwent morphological changes, and expressed more...

Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Utilizing Dynamic Single-Cell Analysis to Discover a Clinically Effective Chimeric Antigen Receptor T-Cell Subset for Treating Diffuse Large B-Cell Lymphoma Research Background Chimeric antigen receptor (CAR) T-cell therapy has been proven to be an effective treatment for B-cell malignancies. However, it remains challenging to predict individual cl...

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...

Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...

The transcription factor Meis2 promotes the development of projection neurons during mouse embryonic development by binding to and activating projection neuron-specific enhancers with Dlx5

This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...

Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients

Immunotherapy Drives Mesenchymal Transition and Tumor Microenvironment Immune Response in Glioblastoma Introduction Glioblastoma is a highly malignant brain tumor with no curative treatment currently available. Although immunotherapy has shown efficacy in other cancer types, the response in glioblastoma patients is limited. Investigating the effect...