Glepaglutide-Loaded Foam for Inducing Mucosal Healing in Inflammatory Bowel Disease Treatment

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging

Research Advances on the Use of Biomimetic Marine Adhesive Protein Coating for Skin Photoaging Prevention Skin photoaging is a significant global health issue, particularly for individuals exposed to prolonged ultraviolet (UV) radiation in outdoor environments. Its manifestations include a reduction in collagen, increased wrinkles, loss of skin ela...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing

A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...

A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...

New Advances in Periodontal Functional Materials Based on Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies

A Review on Novel Periodontal Functional Materials: Comprehensive Exploration of Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies Academic Background and Research Significance With the accelerating trend of global population aging, the concern for oral health issues is increasing. Periodontitis, as a common bacterial infectious ...

Enhancing Immunomodulation and Osseointegration of Bone Implants via Thrombin-Activated Platelet-Rich Plasma Self-Assembly

Enhancing Immunomodulation and Osseointegration of Bone Implants: A Detailed Overview of Thrombin-Activated Platelet-Rich Plasma (PRP) Self-Assembly Technology Background Introduction To address the challenge of bone defect repair, bone implants play a critical role in modern medicine. However, existing bone implant materials like Polyetheretherket...

Biosensors and Biomarkers for the Detection of Motion Sickness

Exploring Biomarkers and Biosensors for Motion Sickness: Innovative Approaches to Diagnostic Challenges Motion sickness (MS) is a common syndrome experienced by humans, triggered by unnatural motions such as those encountered during transportation or virtual reality (VR). It manifests through symptoms like headaches, nausea, vomiting, cold sweats, ...