The Role of Acetyl-CoA Metabolism in Maintaining the Synchronization of Human Trophoblast Stem Cells Research Background and Purpose The placenta is a crucial metabolic bridge between the mother and fetus during pregnancy, and its normal function is vital for the health of both. The placenta constantly differentiates through human trophoblast stem ...
Background and Problem In recent years, there has been significant progress in research on the multifaceted roles of mitochondria within cells. Aside from being the energy source of the cell, mitochondria also play crucial regulatory roles in processes such as cell proliferation, differentiation, and self-renewal, attracting widespread attention in...
Nynrin Protects Hematopoietic Stem Cell Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Background and Research Motivation Hematopoietic stem cells (HSCs) are core cells that maintain the function of the hematopoietic system, showing unique adaptability to stress environments such as radiation damage. However, while conven...
Dynamic Transcriptional Response and Activation of Integrin-YAP/TAZ Survival Signaling Pathway Revealed by Single-Cell Resolution Analysis of Embryo Dormancy Introduction Embryo dormancy, or diapause, is a unique reproductive adaptation that allows some mammals to pause embryonic development without compromising their developmental potential. Diapa...
Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...
Disturbance of Neuronal Homeostasis and Disruption of Neuronal Network Dynamics Caused by Tau Proteinopathy Background and Research Objectives Homeostatic mechanisms play a crucial role in maintaining the stability of brain functions. Under normal circumstances, neuronal activity set-points, such as firing rates, are dynamically adjusted through ho...
This article is a biomedical research paper authored by scholars such as Zhang Tingxin, Bi Cheng, and Li Yiran, published on November 6, 2024, in the journal “Neuron.” The research was led by a team from the Tsinghua University-Peking University Center for Life Sciences, exploring the regulatory mechanism of phosphorylation modification of the mech...
I. Research Background: Neoteny in Human Brain Development and Neurodevelopmental Disorders One of the remarkable features of human brain development is the slow developmental pace of cortical neurons. Compared to other mammals, especially non-human primates, the developmental process of human cortical neurons can last for several years. This neote...
Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...
Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...