Oncolytic Mineralized Bacteria May Be Used for Tumor Immunotherapy via Local Injection Research Background As a novel cancer treatment method, bacteria-based cancer immunotherapy has a long history dating back to the late 19th century when heated, inactivated bacteria were used to treat sarcomas. Initial trials found that these bacteria could trigg...
Constructing Human 3D Striatum-Substantia Nigra Organoids to Model Medium Spiny Neuron Projection Deficits in Huntington’s Disease Background Introduction Huntington’s Disease (HD) is a neurodegenerative disorder leading to significant deterioration of the motor system, primarily characterized by defects in medium spiny neurons (MSNs) that project ...
Physical Immunoevasion: Attenuated Mechanical Communication Facilitates Metastatic Colorectal Cancer Cells to Evade Macrophage Attack Background Introduction Cancer metastasis is a complex and daunting challenge, with metastatic cancer cells capable of evading immune cell attacks, breaching the extracellular matrix (ECM), and migrating to other sit...
Background Introduction In contemporary neuroscience research, dopamine and serotonin are hypothesized to be crucial neuromodulators guiding social behavior. However, there is a significant lack of understanding regarding the dynamic changes of these neuromodulators during social interactions. Although non-invasive functional neuroimaging methods (...
Background Introduction Cancer of Unknown Primary (CUP) is a type of malignant disease that is confirmed to be metastatic through histopathology but whose primary site cannot be identified using conventional baseline diagnostic methods. CUP presents significant diagnostic and therapeutic challenges in clinical practice and is believed to account fo...
The Effectiveness of Bivalent CAR T-Cell Therapy Targeting EGFR and IL13Rα2 in Treating Recurrent Glioblastoma In recent years, the treatment of recurrent glioblastoma (RGBM) has been continually explored and improved, yet overall survival rates remain less than one year, presenting a significant challenge. The limitations of existing treatments an...
GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...
Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...
This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...
The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...