This paper aims to explore the physiological importance of glycolysis in neuronal metabolic processes. For a long time, although neuronal activity mainly relies on glucose for energy, neurons have relatively weak glucose metabolism, mainly through glycolysis rather than other metabolic pathways. This phenomenon can be attributed to the sustained de...
The Coordinating Role of the Hippo-YAP/TAZ Pathway in Adipose Plasticity and Energy Balance Adipose tissue not only serves as an energy storage depot but also functions as an endocrine organ. However, the mechanisms coordinating these functions remain elusive. This study unveiled that the transcriptional co-regulators YAP and TAZ maintain metabolic...
Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...
Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...
Visual Brain-Computer Interface Based on High-Frequency Steady-State Visual Evoked Fields Background Brain-Computer Interface (BCI) technology allows users to control machines by decoding specific brain activity signals. While invasive BCIs excel in capturing high-quality brain signals, their application is mainly limited to clinical settings. Non-...
Comprehensive Academic Report on Scientific Paper Research Background Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS), affecting approximately 2.8 million people worldwide. The pathological mechanisms of this disease are mainly related to autoimmune-mediated demyelination and axonal transectio...
Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps Maintain Respiratory Rate Under Sevoflurane Anesthesia Background Respiration is a core function for maintaining life activities. General anesthetics and/or opioids often suppress respiratory function. However, the respiratory suppression caused by the intravenou...
Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...
Genome-wide screening identifies TRIM33 as an essential regulator of dendritic cell differentiation Background Dendritic cells (DCs) serve as a bridge between innate and adaptive immunity by recognizing pathogens through pattern recognition receptors (such as TLRs) and modulating antigen-specific T cell responses. DCs are mainly divided into two ty...
TDRD3 Deficient Mice Exhibit Deficits in Neurogenesis and Synaptic Plasticity at Both Post-transcriptional and Behavioral Levels Research Background Topoisomerase 3b (top3b) is a dual-activity topoisomerase capable of resolving DNA and RNA topological problems. An increasing body of evidence indicates that top3b functions as a conserved complex wit...