AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...

Phase-Dependent Language Perception in Neural Oscillations: An Interdisciplinary Study Report Background During speech perception, the phase of neural oscillations plays a crucial role in the separation of neural representations and perceptual decisions. However, the specific phase-encoding mechanisms remain unclear. This study aims to reveal how p...

The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...

Childhood Gliomatosis Cerebri: A Poor Prognosis Phenotype of Diffuse Glioma with Distinct Molecular Characteristics Introduction Gliomatosis cerebri (GC) is a highly invasive form of diffuse glioma. It was initially discarded as an independent pathological type due to its indeterminate molecular characteristics. However, with the advancements in mo...

Study on Metabolic Differences between IDH Mutant and Wild-type Glioma Cells Using Raman Spectroscopy and Machine Learning Platform Background Introduction In the diagnosis and treatment of gliomas, formalin-fixed, paraffin-embedded (FFPE) tissue sections are commonly used. However, due to background noise interference from the embedding medium, th...

Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...

Systematic Analysis of NDUFAF6 in Complex I Assembly and Mitochondrial Disease Background Mitochondrial complex I (CI) is a crucial component of the respiratory chain, playing an essential role in oxidative phosphorylation (OXPHOS) by introducing electrons into the mitochondrial respiratory chain and, together with complexes II-IV, generating and m...

Unsaturation of Fatty Acids Promotes Pore-Forming Activity of Bax and Bak in Apoptosis Background Apoptosis is the major form of programmed cell death, involved in fundamental biological processes such as embryonic development, tissue homeostasis, and immune system functions. Dysregulation of apoptosis can lead to neurodegenerative diseases and tum...

Enhancing Super-Resolution Imaging and Volume Electron Microscopy with Deep Learning Algorithms Based on Diffusion Models Background Introduction Electron Microscopy (EM) as a high-resolution imaging tool has made significant breakthroughs in cell biology. Traditional EM techniques are primarily used for two-dimensional imaging, and although they h...

Acetate Reprograms Tumor Metabolism and Promotes Immune Evasion and PD-L1 Expression by Upregulating c-myc Introduction Reprogramming of tumor metabolism is of great significance in cancer research, and acetate plays a crucial role in this process. In tumor cells, acetate is an important precursor of acetyl-CoA, which is used for energy production,...