Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...

CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...

Multimodal Learning Reveals Genotype–Phenotype Dynamics Background The complex relationship between genotype and phenotype has long been a central question in biology. Genotype refers to the genetic information of an organism, while phenotype is the manifestation of this genetic information in a specific environment. Although Wilhelm Johannsen intr...

Mapping the Gene Space at Single-Cell Resolution: A Study on Gene Signal Pattern Analysis (GSPA) Academic Background Single-cell RNA sequencing (scRNA-seq) technology has made significant progress in biological research in recent years, particularly in revealing the organizational structure of the cellular state space. However, although many comput...

Research on Spatial Modeling Algorithms for Cellular Signaling Reactions and Transport Background Biological cells achieve their functions through complex biochemical reaction networks. These networks exhibit significant spatiotemporal dynamics, with pronounced spatial compartmentalization across different regions and subcellular structures. Howeve...

Research Advances on the Use of Biomimetic Marine Adhesive Protein Coating for Skin Photoaging Prevention Skin photoaging is a significant global health issue, particularly for individuals exposed to prolonged ultraviolet (UV) radiation in outdoor environments. Its manifestations include a reduction in collagen, increased wrinkles, loss of skin ela...

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Incorporating Bone-Derived Extracellular Matrix (Bone-Derived ECM) into Macroporous Microribbon Scaffolds Accelerates Bone Regeneration Research Report With the continuous progress in the biomedical field, the application of tissue engineering and regenerative medicine in various tissue repairs has become increasingly important. However, research o...