Academic Background The completion of the Human Genome Project has greatly advanced our understanding of complex biological processes at the genome-wide level. However, only about 1% of the genome encodes proteins, with the majority consisting of non-coding regions that produce abundant non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNA...
Academic Background When plants face pathogen invasion, they activate a series of complex defense mechanisms. Among these, reactive oxygen species (ROS) play a crucial role in plant immune responses. Hydrogen peroxide (H₂O₂), as a major component of ROS, is considered a key signaling molecule in plant immunity. However, how H₂O₂ is sensed within pl...
Academic Background Heat Acclimation (HA) is a key adaptive response in mammals to repeated exposure to high temperatures, essential for improving cardiovascular function, thermal comfort, and exercise capacity. However, due to the lack of genetically tractable models, the molecular and neural mechanisms underlying HA have not been fully elucidated...
Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...
Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...
Academic Background During embryonic development, arteriovenous differentiation (AV differentiation) is a critical step in ensuring proper blood vessel formation and maturation. Defects in arterial or venous identity can lead to inappropriate fusion of vessels, resulting in so-called arteriovenous malformations (AVMs). Currently, the mechanism behi...
The Critical Role of RNA-Binding Protein RBPMS in Vascular Smooth Muscle Cells Academic Background Vascular Smooth Muscle Cells (VSMCs) are the primary structural components of large arteries. In healthy blood vessels, VSMCs exhibit a mature contractile phenotype, responsible for regulating vascular tone and blood flow. However, VSMCs possess pheno...
During tumor development, copy number alterations (CNAs) are key drivers of tumor heterogeneity and evolution. Understanding these variations is crucial for developing personalized cancer diagnostics and therapies. Single-cell sequencing technology offers the highest resolution for copy number analysis, down to the individual cell level. However, l...
Background Introduction Post-Translational Modifications (PTMs) are crucial mechanisms for regulating cellular activities, including gene transcription, DNA repair, and protein interactions. Among these, cysteine, a rare amino acid, participates in various PTMs through its thiol group, playing a significant role in redox balance and signal transduc...