Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...
How COVID-19 Vaccines Affect Immune Responses During Breakthrough Infections Background Introduction As the COVID-19 pandemic continues, an increasing number of infections are “breakthrough infections,” occurring in individuals who have been vaccinated or previously infected with SARS-CoV-2. Although vaccination has significantly reduced the risk o...
Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...
PD-L1 in Tumor-Derived Extracellular Vesicles Promotes T Cell Senescence through Lipid Metabolism Reprogramming Academic Background In recent years, immunotherapy has shown great promise in cancer treatment, particularly in checkpoint blockade therapies targeting PD-1/PD-L1 (programmed cell death protein 1 and its ligand) and CTLA-4 (cytotoxic T-ly...
Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...
Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...
Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...
Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...
High-Precision Prediction of Protein Fragment Inhibitory Activity: The Application of FragFold Academic Background Protein interactions play a crucial role in cellular life activities, and peptides or protein fragments can regulate protein functions by binding to specific protein interfaces, even acting as inhibitors. Recent developments in high-th...
Academic Background In cell biology, focal adhesions (FAs) are key connection points between cells and the extracellular matrix (ECM), linking integrin receptors to the intracellular actin cytoskeleton. They play a crucial role in cell migration and polarization. Talin is a core protein in focal adhesions that directly connects integrin receptors t...