Inhibition of the electron transport chain increases cell dependence on purine transport and salvage Research Background The electron transport chain (ETC) is a key mechanism in mitochondria responsible for energy generation, playing an important role in maintaining cellular homeostasis and growth. However, it remains unclear how cells adjust their...
Obesity Disrupts Pituitary-Hepatic UPR Communication Leading to NAFLD Progression Background and Research Objectives In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly. Research suggests that obesity, a major risk factor for NAFLD, disrupts hepatic immunometabolic homeostasis by affecting systemi...
A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...
The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...
Fatty Acid Oxidation in Lung Cancer Patients Induced by Sleep Loss Promotes Tumorigenesis Through Circadian Rhythm Disruption Background and Research Motivation Circadian rhythm regulation is one of the critical mechanisms for animals to maintain physiological homeostasis. However, disruptions in circadian rhythms have become a common phenomenon du...
The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....
The Direct Link between Cytosolic pH and Environmental Signals, Insulin Processing, and Secretion in Pancreatic β Cells Background Pancreatic β cells respond to glucose fluctuations by regulating insulin processing and secretion. However, how this process is finely tuned within a complex and variable microenvironment, and whether its dysfunction is...
Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...
Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...
Browning of Subcutaneous White Adipose Tissue and Skin Repair Efficiency Current scientific research reveals that the participation of various cells is essential in the process of skin repair and regeneration. Among these, adipocytes (fat cells) have attracted attention due to their primary role in energy storage and critical endocrine functions in...