Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...
A New Platform for Efficient Signal Amplification of Nucleic Acid Targets in Tissue and Clinical Research: PSABER Background and Related Knowledge Since its first introduction by Pardue and Gall in the 1960s, in situ hybridization (ISH) has been widely adopted in research and clinical applications for its ability to spatially map nucleic acid targe...
The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...
Mitochondrial Transfer and Immune Evasion Mechanisms in the Tumor Microenvironment Academic Background Tumor cells evade immune system attacks, particularly by T cells, through various mechanisms in the Tumor Microenvironment (TME). Although Immune Checkpoint Inhibitors (ICIs) have achieved significant progress in the treatment of various cancers, ...
Precise Modeling of Mitochondrial Diseases: Research Based on Optimized Mitobes Academic Background Mitochondrial diseases are a group of genetic disorders caused by mutations in mitochondrial DNA (mtDNA), which affect cellular energy metabolism and lead to dysfunction in multiple organs. Mitochondrial DNA mutations can be homoplasmic (affecting al...
Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...
Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...
Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...
The Interaction Between A2A Receptor and CB1 Receptor in GABA and Glutamate Release in the Basal Ganglia Background The basal ganglia are key structures in the brain responsible for motor control and reward-based behaviors. They receive excitatory inputs from the cortex and thalamus, with 80% of the synapses being glutamatergic, while the second mo...
Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...