Background and Problem In recent years, there has been significant progress in research on the multifaceted roles of mitochondria within cells. Aside from being the energy source of the cell, mitochondria also play crucial regulatory roles in processes such as cell proliferation, differentiation, and self-renewal, attracting widespread attention in...

Nynrin Protects Hematopoietic Stem Cell Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Background and Research Motivation Hematopoietic stem cells (HSCs) are core cells that maintain the function of the hematopoietic system, showing unique adaptability to stress environments such as radiation damage. However, while conven...

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...

Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...

Paper Report: The Role of MDH2 in Epitranscriptomic Metabolic Regulation of Glioblastoma Stem Cells Introduction and Background Glioblastoma (GBM) is the most common and lethal primary brain malignant tumor in adults. GBM cells utilize a metabolic pathway known as the Warburg effect, which involves increased glucose uptake through aerobic glycolysi...

Fructose Promotes Colorectal Cancer Growth by Modulating Tumor-Associated Macrophage Polarization Introduction In recent years, fructose intake has dramatically increased worldwide and is closely associated with obesity and metabolic syndrome, both of which are recognized risk factors for cancer development. Although previous studies have shown tha...

Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...

The Loss of β-arrestin 2 in Hepatic Macrophages Alleviates Metabolic Dysfunction-associated Steatohepatitis — Through Metabolic Reprogramming of Macrophages Background and Motivation Metabolic dysfunction-associated fatty liver disease (MASLD) is a globally prevalent health issue, affecting approximately 25% of the population. This disease includes...

Research on SGLT2 Inhibitors Alleviating MASH by Enhancing Ketogenesis to Inhibit CD8+ T Cell Activation Research Background and Problem Positioning Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become a global health concern. Its severe stage, Metabolic Dysfunction-Associated Steatohepatitis (MASH), leads to hepatocyte damag...

Novel Subpopulation of Adipose Tissue Macrophages IMAMs and Their Role in Obesity and Metabolic Disorders Background Obesity is an increasingly severe health issue worldwide, often accompanied by a state of chronic low-grade inflammation. This condition is driven by the infiltration and dysfunction of immune cells within adipose tissue and other me...