Research Report: Reshaping Functional Hierarchies in Medication-Refractory Essential Tremor Through MRgFUS Therapy Essential tremor (ET), a prevalent movement disorder, is characterized by involuntary limb tremors, particularly noticeable during specific tasks. While traditional pharmacological treatments and deep brain stimulation (DBS) have shown...
Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...
Background and Research Motivation Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons, leading to progressive muscle paralysis and eventual death. Currently, no effective treatments can significantly delay or halt ALS progression. While various ALS mouse models (such as those carry...
Research Report on the Improvement of CMT-like Neuropathy via AAV9 Vector-based C1ORF194 Gene Therapy Background and Research Motivation Charcot-Marie-Tooth disease (CMT) is a rare group of genetically heterogeneous neuromuscular disorders characterized by progressive muscle weakness and atrophy, along with sensory loss. Despite extensive preclinic...
GYS1 Antisense Therapy Inhibits Pathogenic Aggregates and Epileptiform Discharges in a Mouse Model of Lafora Disease Background and Objectives Lafora disease (LD) is a devastating autosomal recessive genetic disorder characterized by epilepsy and rapidly progressive dementia in adolescence. The disease primarily involves mutations in the EPM2A or E...
D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...
Developing a Novel Erythrocyte-MHC-I Conjugate for Cancer Treatment: A Revolutionary Immunotherapy Research Background: Traditional Roles and Newly Discovered Potential Erythrocytes, or red blood cells, are the most abundant cells in the human body, comprising approximately 70% of total cell count in adults. Traditionally recognized for their role ...
Crossing the Blood–Brain Barrier: Study on Adipose-Derived Stem Cells as Carriers for Pro-Apoptotic Oncolytic Myxoma Virus in the Treatment of Murine Glioblastoma Background and Objective Glioblastoma (GBM) is among the most invasive and aggressive brain tumors, characterized by high recurrence rates and poor prognosis. Despite multimodal intervent...
Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness, Increasing Anti-PD-1 Therapy Responsiveness in Glioblastoma Background and Objectives of the Study Glioblastoma (GBM) is an aggressive central nervous system tumor with poor prognosis, and the median survival of patients is only 14.6 months. Despite the significant efficacy of immune ch...
New Discovery in Metabolic Regulation of Muscle Stem Cell Activation: The Crucial Role of the Spermidine-eIF5A Axis Background and Research Objectives Adult skeletal muscle satellite cells (SCs) are the main type of stem cells in skeletal muscle and play a pivotal role in muscle injury repair. However, the activation mechanism of quiescent satellit...