Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...
Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...
Deciphering the Topological Landscape of Glioma: A Study Based on a Network Theory Framework Glioma stem cells (GSCs) are recognized as key factors in glioma recurrence and treatment resistance, making them an important focus for new therapeutic approaches. However, the limited understanding of the role of GSCs in the hierarchy of glioma has sparke...
New Insights into CNS Disease Immunology Mechanisms Revealed by Multidimensional Flow Cytometry In immunological research, understanding the immunopathological mechanisms of central nervous system (CNS) diseases is crucial for early diagnosis and treatment decisions. A study published in Journal of Neuroinflammation in 2024 used multidimensional fl...
Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...
Targeting Chemotherapy-Induced Adaptive Signaling Circuitry for Therapeutic Potential in Pancreatic Cancer Background Introduction Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with a five-year survival rate that remains extremely low. Over 80% of patients are diagnosed at an advanced, unresectable stage, where existin...
Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...
Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...
Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...
Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...