Spatiotemporal Regulation of KLF2 and T-bet by Eomesodermin During NK Cell Development I. Research Background Natural Killer (NK) cells are important cells in the immune system, capable of recognizing and killing tumor cells and pathogen-infected cells. The generation and development of NK cells depend on the gradual acquisition of a series of spec...

Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...

Scientific Research Report: The Protective Role of Integrin α4β7 and Type 2 Innate Lymphoid Cells in Nephritis In a recent study, an international research team led by Dr. Seungwon Ryu revealed the critical protective role of integrin α4β7 and Type 2 Innate Lymphoid Cells (ILC2s) in nephritis caused by Systemic Lupus Erythematosus (SLE). The study ...

Targeting STING in Dendritic Cells Alleviates Psoriatic Inflammation Psoriasis is a common chronic inflammatory skin disease primarily caused by abnormal activation of dendritic cells (DCs) and T cells, ultimately leading to increased cytokines such as interleukin (IL)-23 and IL-17A. The cGAS-STING pathway is known to play a key role in psoriatic i...

Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...

Automated Clinical Assessment of Abnormal Walking Movements in ABI Patients Through Image Extraction and Classification Systems Academic Background Walking disability is a common physical impairment following Acquired Brain Injury (ABI). ABI typically includes stroke and traumatic brain injury, with a global incidence of approximately 1.5 million c...

Custom Passive Dynamic Ankle-Foot Orthoses Can Improve Walking Economy and Speed Post-Stroke Background Introduction Stroke is one of the leading causes of long-term disability, affecting over 795,000 individuals annually in the United States. A common post-stroke issue is plantar flexor weakness in the affected limb, impacting the ability to contr...

Safety and Efficacy: The Impact of Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation Background Stroke is the leading cause of disability among adults in the United States, with up to 80% of stroke survivors experiencing gait impairments, such as reduced walking speed, endurance, and asymmetrical gait, thereby limiting their ability to wa...

The Impact of Exoskeleton Rehabilitation Robot Training on Balance and Lower Limb Function in Subacute Stroke Patients: A Preliminary, Randomized Controlled Trial Research Background and Purpose Stroke is a leading cause of death and disability worldwide. With the rapid development of stroke treatment technology, the mortality rate of stroke has si...

Robot-Assisted Assessment of Chronic Stroke Adults’ Ankle Proprioception Deficits and Related Brain Injury Academic Background Stroke is a common neurological disorder, often resulting in hemiplegia, which affects the patient’s balance and gait control. Proprioception refers to the self-perception of body posture and movement, provided by mechanore...