Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Wireless Injectable Ultrasound Sensor for Intracranial Signal Monitoring Background Introduction Direct and accurate monitoring of intracranial physiological conditions is extremely important for injury classification, prognosis assessment, and disease prevention. However, traditional wired clinical devices, such as percutaneous leads, although per...

Automated Spinal Cord Segmentation Pipeline Based on Convolutional Neural Network (CNN) for Individualized Cat Spinal Cord Stimulation Modeling Background and Research Motivation Spinal cord stimulation (SCS) is a widely used treatment method for chronic pain management. In recent years, it has also been used to modulate neural activity, aiming to ...

Feasibility of Intravascular Femoral Nerve Stimulation using a Stent Electrode Array In recent years, electrical stimulation of peripheral nerves has gained attention as a potential therapeutic approach for restoring impaired nerve function. Traditional electrode arrays typically require invasive surgical implantation, which imposes a significant b...

Background Introduction The study of Event-Related Potentials (ERPs) provides important information about brain mechanisms, particularly in elucidating various psychological processes. In these studies, multi-channel electroencephalograms (EEGs) are typically recorded while subjects perform specific tasks, and the trials are categorized based on st...

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury Traumatic brain injury (TBI) is a serious neurological disorder, and the complexity of its treatment has long plagued the medical community. TBI not only leads to immediate loss of neurological function in patients, but also causes long-term tis...

Layer-Dependent Effects of Chronic Neural Electrode Implants on Neural Functional Connectivity in Mice Introduction This study explores the long-term effects of chronically implanted microelectrodes on neural functional connectivity within the brains of C57BL6 wild-type mice. Implanted intracerebral electrodes enable the recording and electrical st...

Topology of Surface Electromyography Signals: Decoding Hand Gestures Using Riemannian Manifolds This paper is authored by Harshavardhana T. Gowda (Department of Electrical and Computer Engineering, University of California, Davis) and Lee M. Miller (Center for Mind and Brain Sciences, Department of Neurophysiology and Behavior, Department of Otolar...

Influence of Peripheral Nerve Geometry and Local Anatomy on Magnetic Stimulation Time Constant Background Introduction Rapidly switching magnetic resonance imaging (MRI) gradient fields produce sufficiently strong electric fields within the human body, leading to peripheral nerve stimulation (PNS), which limits improvements in imaging speed and res...