Functional Correlation between Myeloid Cells and Membrane Abundance

In the past few decades, with the rapid development of science and technology, human understanding of the immune system has continuously deepened. Among all immune cells, professional phagocytes (such as neutrophils and macrophages) play a crucial role in clearing apoptotic cells, cell debris, and invading pathogens. These cells uptake and engulf f...

Overexpression of MALAT1 Drives Metastasis Through Inflammatory Reprogramming of the Tumor Microenvironment

Cancer Immunology Research: Overexpression of MALAT1 Drives Lung Adenocarcinoma Metastasis Through Inflammatory Reprogramming Background Introduction MALAT1 (Metastasis-associated Lung Adenocarcinoma Transcript 1) is a long noncoding RNA (lncRNA) closely linked to tumor progression and metastasis in several cancers, including lung adenocarcinoma (L...

A Lactate-SREBP2 Signaling Axis Drives Tolerogenic Dendritic Cell Maturation and Promotes Cancer Progression

Cancer Immunology Lactate-SREBP2 Signaling Axis-Driven Tolerogenic Dendritic Cell Maturation and Its Role in Promoting Cancer Progression Background In cancer, conventional dendritic cells (DCs) are key mediators of anti-tumor immunity. However, cancer has evolved mechanisms that render DCs ineffective in the tumor microenvironment (TME), and these...

Gfi1b Specifies Developmental Potential of Innate Lymphoid Cell Progenitors in the Lungs

Background Introduction In respiratory diseases, the lung is a sensitive organ exposed to the external environment, making it susceptible to pathogens, allergens, and toxic particles. Due to the high morbidity and mortality associated with respiratory diseases (such as asthma), it is crucial to study the mechanisms protecting the cells on the surfa...

Single-Cell Topographical Profiling of the Immune Synapse Reveals a Biomechanical Signature of Cytotoxicity

Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...

Characterization of early inflammatory responses and cytokine changes during schistosome infection

对于一篇关于血吸虫感染早期反应的深入研究,Houlder等人撰写的论文为科学界提供了重要的见解。他们的研究发表于《科学免疫学》(Sci. Immunol.) 2024年7月5日的第9卷,揭示了血吸虫(Schistosoma mansoni...

MAIT Cells Monitor Intestinal Dysbiosis and Contribute to Host Protection During Colitis

MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...

Conformation- and Activation-Based BRET Sensors Differentially Report on GPCR-G Protein Coupling

Differential Study of GPCR-G Protein Coupling Biosensors Background Introduction G protein-coupled receptors (GPCRs) are important molecules for transmembrane signal transduction, capable of selectively binding to heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits and regulating various intracellular signaling processes. Studying the fun...

G Protein–Coupled Receptor Endocytosis Generates Spatiotemporal Bias in β-Arrestin Signaling

Academic News Report: The Temporal and Spatial Bias in β-arrestin Signal Transduction Mediated by G Protein-Coupled Receptor Endocytosis Research Background Among cell surface receptor families, G protein-coupled receptors (GPCRs) constitute the largest family. Upon activation by ligands, they interact with various signaling proteins to trigger int...

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...