IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells

Review on the Study of IL-12 Promoting Human Follicular Regulatory T Cell Differentiation Research Background Follicular helper T cells (Tfh) play a crucial regulatory role in B cell responses to pathogens and vaccines. When not properly controlled, Tfh cells can lead to the production of antibodies against self-antigens or allergens. Follicular re...

Engineered Mini-G Proteins Block the Internalization of Cognate GPCRs and Disrupt Downstream Intracellular Signaling

Mini G Protein Inhibits Internalization of Same GPCR and Disrupts Downstream Intracellular Signaling Introduction G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, regulating cellular responses to external stimuli such as hormones and neurotransmitters. GPCRs transmit signals by coupling with guanine nucleotide-bi...

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...

YAP Represses the TEAD–NF-κB Complex and Inhibits the Growth of Clear Cell Renal Cell Carcinoma

YAP Inhibits the TEAD-NF-κB Complex and Suppresses the Growth of Clear Cell Renal Cell Carcinoma Research Background Conventionally, the Hippo signaling pathway inhibits YAP-TEAD transcriptional complexes by keeping the transcriptional coactivator YAP phosphorylated and retained in the cytoplasm, thereby impeding tumor growth. However, researchers ...

Cytokines Drive the Formation of Memory-Like NK Cell Subsets via Epigenetic Rewiring and Transcriptional Regulation

Cytokines Drive the Formation of Memory-Like NK Cell Subsets via Epigenetic Rewiring and Transcriptional Regulation

In the context of today’s rapid advancement in science and technology, immunotherapy with natural killer (NK) cells has attracted widespread attention in the scientific community for their potential advantages in combating tumors and viral infections. Especially, the discovery of memory-like NK cells has brought new hope for NK cells as an anticanc...

Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges

Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges

Research Report on Multi-sensory Flicker Regulating Extensive Brain Networks and Reducing Interictal Epileptiform Discharges Background Introduction In treating neurological disorders, modulating brain oscillations has great potential. Non-invasive interventions, suitable for everyday use at home, have become the focus of the scientific community, ...

Prediction error processing and sharpening of expected information

Prediction error processing and sharpening of expected information

Scientific Report Background Introduction Perception and neuronal processing of sensory information are largely influenced by prior expectations. Perception is not merely passive reception, but an active inferential process by combining existing sensory information with prior information based on past experience and current context. The combination...

Revealing the Mechanisms of Semantic Satiation with Deep Learning Models

Revealing the Mechanisms of Semantic Satiation with Deep Learning Models

Deep Learning Model Reveals Mechanisms of Semantic Satiation Semantic satiation, the phenomenon where a word or phrase loses its meaning after being repeated many times, is a well-known psychological phenomenon. However, the micro-neural computational principles underlying this mechanism remain unknown. This paper uses a continuous coupled neural n...

Electrophysiological Signatures of Veridical Head Direction in Humans

Electrophysiological Signatures of Veridical Head Direction in Humans

Electrophysiological Signatures of Veridical Head Direction in Humans Navigation is one of the core components of human complex cognition, where head direction information is crucial for positioning oneself in space. However, due to the requirement of having the head fixed in a specific position during most neuroimaging experiments, understanding h...

Ventral Subiculum Promotes Wakefulness Through Several Pathways in Male Mice

The Ventral Subiculum Promotes Wakefulness Through Multiple Pathways in Male Mice Background The ventral subiculum (vsub) is a major output region of the hippocampus, playing a crucial role in motivation, stress integration, and anxiety-like behavior, all of which depend on a high state of wakefulness. However, the role of vsub in wakefulness and i...