Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...

The Effect of Nudcd3 Deficiency on V(D)J Recombination In the study of congenital immunodeficiency, especially in the field of T cell developmental abnormalities, identifying key genes and pathways is of great significance. Researches on Severe Combined Immunodeficiency (SCID) and Omenn Syndrome (OS) have highlighted the crucial roles of T cell rec...

Background Introduction The immune system plays a crucial role in responding to viral infections, and T cell memory is especially important in secondary immune responses. This paper focuses on how resident memory T cells (LN TRMs) in lymph nodes are formed after skin infections. LN TRMs play a key role in immune memory at specific sites, but their ...

Heart Failure Promotes Multimorbidity through Innate Immune Memory Background Introduction Heart failure (HF) is a common and fatal disease. Despite continuous advancements in medical technology, the mortality rate of heart failure remains high. HF patients frequently experience recurrent acute decompensation, which not only leads to the continuous...

Research Background γδ T cells play an important role in the immune system, particularly in protective immunity, homeostasis, and tissue repair. Unlike conventional αβ T cells, which are restricted by major histocompatibility complex (MHC), γδ T cells directly seed peripheral tissues and respond to various microbial stimuli without relying on MHC-p...

Inducing Immune Tolerance through Peripheral Clonal Deletion Targeting PD-1 Expressing Cells Background Introduction The establishment of T-cell receptor (TCR) repertoire through thymic negative selection is a key process for achieving self-tolerance and acquired tolerance post-organ transplantation. However, it remains unclear whether the specific...

New Findings on the Detection of Single-Stranded DNA by the Human Immune System: The Role of Schlafen 11 in Innate Immune Response Research Background In the innate immune system, pattern recognition receptors (PRRs) play a crucial role. They initiate an immune response by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associ...

Report: Intrinsic Role of m6A Reader Protein YTHDF2 in Regulating Tumor Immune Evasion Background Introduction In recent years, immunotherapy has become a hotspot in the field of tumor treatment, attracting attention for its ability to break through immune suppression barriers or enhance existing anti-tumor immunity. However, despite some successes...

Tumor Immunology Research: The Exhausted State of CD8+ T Cells in Tumors In recent years, immunotherapy has achieved significant progress in the field of tumor treatment. However, tracking the behavior of lymphocytes following antigen signals remains challenging. This study aims to address this issue by developing Antigen Receptor Signaling Reporte...

Tissue-Resident Capacity of Long-Term Surviving KLRG1+ Effector Memory T Cells Background Memory CD8 T cells play a crucial role in the body’s defense against pathogen reinfection. Memory T cells are a heterogeneous group of cells present in various tissues throughout the body, providing essential surveillance and rapid response functions. Memory T...