Study Reveals Tirzepatide Regulates Adipocyte Nutritional Metabolism Through Long-Acting Activation of GIP Receptor Academic Background With global chronic nutritional excess and lack of exercise, obesity and type 2 diabetes (T2D) and their related complications (such as cardiovascular diseases) have reached epidemic levels. These conditions not on...
Obesity Disrupts Pituitary-Hepatic UPR Communication Leading to NAFLD Progression Background and Research Objectives In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly. Research suggests that obesity, a major risk factor for NAFLD, disrupts hepatic immunometabolic homeostasis by affecting systemi...
A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...
The New Protein Cytb-187aa Regulates Mammalian Early Development Academic Background Mitochondria are multifunctional organelles that provide energy for cells. In addition to energy supply, they are involved in the regulation of apoptosis, cell signaling, and various biosynthetic pathways. Among these functions, substances within mitochondria can b...
Fatty Acid Oxidation in Lung Cancer Patients Induced by Sleep Loss Promotes Tumorigenesis Through Circadian Rhythm Disruption Background and Research Motivation Circadian rhythm regulation is one of the critical mechanisms for animals to maintain physiological homeostasis. However, disruptions in circadian rhythms have become a common phenomenon du...
The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....
The Direct Link between Cytosolic pH and Environmental Signals, Insulin Processing, and Secretion in Pancreatic β Cells Background Pancreatic β cells respond to glucose fluctuations by regulating insulin processing and secretion. However, how this process is finely tuned within a complex and variable microenvironment, and whether its dysfunction is...
Myocardial Infarction Accelerates the Progression of Metabolic Dysfunction-Associated Steatohepatitis by Inducing Immune Inflammatory Response and Periostin Background and Study Motivation Metabolic-associated steatohepatitis (MASLD, formerly NAFLD) is one of the most common chronic liver diseases worldwide, affecting about 25% of the adult populat...
Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...
Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...