Hormone Therapy Enhances Anti-PD1 Efficacy in Premenopausal Estrogen Receptor-Positive and HER2-Negative Advanced Breast Cancer

Hormone Therapy Enhances Anti-PD-1 Efficacy: A Breakthrough Study Targeting Estrogen Receptor-Positive/HER2-Negative Metastatic Breast Cancer Background: Why Conduct This Study? In recent years, cancer immunotherapies have achieved transformative success, with notable efficacy in “hot tumors,” such as triple-negative breast cancer (TNBC), which hav...

High Cellular Plasticity State of Medulloblastoma: Local Recurrence and Distant Dissemination

High Cellular Plasticity State of Pediatric Medulloblastoma: A Comprehensive Analysis of Local Recurrence and Distant Dissemination Research Background Medulloblastoma (MB) is a highly heterogeneous pediatric intracranial malignancy. While current treatments (surgery, radiotherapy, and chemotherapy) improve survival rates after initial treatment, r...

Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-positive breast cancer risk

Exploring the Impact of Endocrine-Targeting Therapies on Breast Microbiota and Their Potential in Breast Cancer Prevention and Treatment Breast cancer is one of the most commonly diagnosed types of cancer in women. Despite significant advancements in diagnosis and treatment, the mortality rate remains high, with over 40,000 deaths annually in the U...

Dual Ferroptosis Induction in N2-TANs and TNBC Cells via FTH1 Targeting: A Therapeutic Strategy for Triple-Negative Breast Cancer

Dual Ferroptosis Induction via FTH1 Targeting: A New Therapeutic Strategy for Triple-Negative Breast Cancer (TNBC) Background: Why Conduct This Study? Breast cancer is one of the most common cancer types worldwide, accounting for 11.7% of all new cancer cases globally. Among its several subtypes, triple-negative breast cancer (TNBC) stands out for ...

Single-Molecule Systems for the Detection and Monitoring of Plasma-Circulating Nucleosomes and Oncoproteins in Diffuse Midline Glioma

Exploring the Applications of Single-Molecule Systems for Detection and Monitoring of Plasma-Circulating Nucleosomes and Oncoproteins in Diffuse Midline Glioma Research Background and Problem Overview Diffuse Midline Glioma (DMG) is a highly aggressive brain tumor primarily affecting children with extremely high mortality rates. This type of tumor ...

Oncolytic Cytomegaloviruses Expressing EGFR-Retargeted Fusogenic Glycoprotein Complex and Drug-Controllable Interleukin-12

Oncolytic Cytomegaloviruses Expressing EGFR-Retargeted Fusogenic Glycoprotein Complex and Drug-Controllable Interleukin-12

The Potential of Oncolytic Cytomegaloviruses Expressing EGFR-Retargeted Fusogenic Glycoprotein Complex and Drug-Controlled IL-12 in Cancer Immunotherapy Background and Objectives In recent years, cancer viroimmunotherapy has emerged as a promising research focus in the field of cancer treatment. This therapy leverages viruses to infect tumor cells,...

Neoadjuvant Chemotherapy by Liposomal Doxorubicin Boosts Immune Protection of Tumor Membrane Antigens-Based Nanovaccine

Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...

Metabolic Profiling Reveals Nucleotide Synthesis as a Metabolic Vulnerability in Malignant Rhabdoid Tumors

Tumor Metabolic Reprogramming Identifies Key Vulnerability in Pediatric Malignant Tumors – Comprehensive Research Based on Organoid Models Background Malignant Rhabdoid Tumors (MRT) are highly invasive pediatric cancers that primarily affect infants and can develop throughout the body, with the intracranial variant known as Atypical Teratoid/Rhabdo...

Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma

Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...

Coupling of Response Biomarkers Between Tumor and Peripheral Blood in Chemoimmunotherapy

Background Introduction This study focuses on malignant pleural mesothelioma (MPM), a rare and highly lethal cancer strongly associated with asbestos exposure. Most patients are diagnosed at advanced stages, with a survival time of only 12 to 15 months, and traditional treatments revolve around platinum-based chemotherapy. However, treatment paradi...