I. Research Background: Neoteny in Human Brain Development and Neurodevelopmental Disorders One of the remarkable features of human brain development is the slow developmental pace of cortical neurons. Compared to other mammals, especially non-human primates, the developmental process of human cortical neurons can last for several years. This neote...

Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...

Disruption of Nucleolar Integrity and Dysregulation of RNA Splicing in C9orf72-FTD/ALS Background and Research Motivation The hexanucleotide repeat expansion (GGGGCC)n in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Studies have shown that these repeat sequences not only...

Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...

I. Research Background The taste of food has a significant impact on the feeding motivation of animals. Previous research has shown that taste, as a positive feedback signal, can enhance the feeding motivation of animals. However, in recent years, studies on whether taste also plays a role in suppressing feeding and helping achieve negative feedbac...

Structural Basis of LSD Recognition in Dopamine D1 Receptors Research Background and Problem Statement LSD (lysergic acid diethylamide) is a well-known hallucinogen that primarily exerts profound cognitive and perceptual effects by acting on various neurotransmitter receptors, including serotonin (5-HT) receptors and dopamine receptors. The 5-HT2A ...

Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...

Study on the Effect of Glucose Regulation on Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Patients with Fatty Liver Disease Research Background and Significance Metabolic-dysfunction-associated Steatotic Liver Disease (MASLD) has become one of the major challenges in global health in the 21st century. This condition is often acc...

Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...