Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...
Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...
Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...
Research on a New Platform for Tumor-Specific Drug Delivery Targeting the Warburg Effect Cancer remains a global health challenge. Traditional cancer treatments, such as chemotherapy and radiotherapy, often come with significant side effects due to their inability to distinguish between tumor tissues and healthy tissues, leading to damage in the la...
Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...
Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...
Research Report: Mitochondrial Uncouplers Inhibit E2F1 Activity and Prostate Cancer Growth Background Prostate cancer (PC) is the most common cancer and the second leading cause of cancer-related deaths among men in the United States. In 2024, an estimated 299,010 American men will be diagnosed with prostate cancer, and 35,250 will die from the dis...
A Novel GLUT1-Targeted Fluorescence Imaging Tracer: Advances in Intraoperative Breast Cancer Detection Background and Problem Statement Breast cancer is one of the most common malignancies among women worldwide, with an estimated 2.3 million new cases and approximately 666,000 deaths globally in 2022. Surgical treatment for breast cancer typically ...
A Novel Near-Infrared Fluorescence Imaging Study Targeting Hepatocellular Carcinoma (HCC) Hepatocellular carcinoma (HCC) ranks as the sixth most common malignancy and the third leading cause of cancer-related mortality worldwide. Statistics indicate that the postoperative recurrence rate of HCC reaches as high as 80%, with liver fibrosis or cirrhos...
Development of a Molecular Probe for Tumor-Associated Protein Mesothelin Based on PET Imaging Technology Research Background In recent years, mesothelin (MSLN) has become a key focus in cancer research and diagnostics. Mesothelin is a membrane-bound glycoprotein highly expressed on the surface of various malignancies, including ovarian, pancreatic,...