A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

A Review on Novel Periodontal Functional Materials: Comprehensive Exploration of Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies Academic Background and Research Significance With the accelerating trend of global population aging, the concern for oral health issues is increasing. Periodontitis, as a common bacterial infectious ...

Enhancing Immunomodulation and Osseointegration of Bone Implants: A Detailed Overview of Thrombin-Activated Platelet-Rich Plasma (PRP) Self-Assembly Technology Background Introduction To address the challenge of bone defect repair, bone implants play a critical role in modern medicine. However, existing bone implant materials like Polyetheretherket...

Exploring Biomarkers and Biosensors for Motion Sickness: Innovative Approaches to Diagnostic Challenges Motion sickness (MS) is a common syndrome experienced by humans, triggered by unnatural motions such as those encountered during transportation or virtual reality (VR). It manifests through symptoms like headaches, nausea, vomiting, cold sweats, ...

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...

New Advances in Dual-Targeting Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy: Phase 1⁄2 Clinical Trial of Brogidirsen Background Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder primarily affecting skeletal and cardiac muscles, leading to early loss of mobility and, eventually, organ failure. Currently, there is no ...

Hormone Therapy Enhances Anti-PD-1 Efficacy: A Breakthrough Study Targeting Estrogen Receptor-Positive/HER2-Negative Metastatic Breast Cancer Background: Why Conduct This Study? In recent years, cancer immunotherapies have achieved transformative success, with notable efficacy in “hot tumors,” such as triple-negative breast cancer (TNBC), which hav...