Alleviating CB2-dependent ER stress and mitochondrial dysfunction improves chronic cerebral hypoperfusion-induced cognitive impairment

Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment via the CCL20/CCR6 Axis in Human Hepatocellular Carcinoma

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment in Human Hepatocellular Carcinoma via the CCL20/CCR6 Axis Background Macrophages are a major component of the tumor microenvironment (TME) and regulate the entire tumor process. In the TME, macrophages exhibit dynamic heterogeneity and plasticity, which affects their role ...

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through Erk1/2 nuclear export

Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...

Depleting Profibrotic Macrophages Using Bioactivated In Vivo Assembly Peptides Ameliorates Kidney Fibrosis

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...

Mechanistic Study on SENP6 Regulation of IFN-I Signaling Pathway and Antiviral Activity

Academic Background and Research Question In antiviral efficacy research, type I interferon (IFN-I) has been widely used clinically due to its broad-spectrum antiviral properties. However, the specific signaling mechanism and regulatory modes of IFN-I remain complex and not fully elucidated. In light of this, experts have begun to pay attention to ...

Chaperone- and PTM-mediated Activation of IRF1 Tames Radiation-induced Cell Death and the Inflammatory Response

Study on IRF1 Transcriptional Activation Regulation of Radiation-Induced Cell Death and Inflammatory Response under Mutagenic Stress Background Recent multi-omics studies have revealed the key role of structural cells in immune regulation, but the mechanism remains unclear. Based on this, this study mainly explores how the transcriptional activatio...

HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model

Research Background and Research Questions Spondyloarthritis (SpA) is a typical disease characterized by type 3 immune-driven inflammation and new bone formation (NBF). Although previous studies have shown that Macrophage Migration Inhibitory Factor (MIF) plays a key role in the pathogenesis of SpA, its interactions with other molecules and specifi...

Distinct Palmitoylation of FoxP3 Regulates the Function of Regulatory T Cells via Palmitoyltransferases

Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...

Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body

The purpose of this paper is to explore the developmental origin, biological characteristics, and association with eye diseases of tissue-resident macrophages in the field of ophthalmology—hyalocytes. The eye is a highly specialized sensory organ that contains the retina, part of the central nervous system, as well as non-neuronal parts like the tr...