Prognostic Model of Pulmonary High-grade Neuroendocrine Carcinoma: Integrating Genomic Analysis and Poly(ADP-ribose) Polymerase-1 Expression Research Background High-grade neuroendocrine carcinoma (HGNEC) of the lung is a highly aggressive cancer with significant biological complexity. Despite its association with Notch pathway activation and inact...

Ovarian cancer is one of the most common and deadly tumor types in women. In recent years, Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown encouraging clinical results in the treatment of ovarian cancer. Numerous studies have found that patients with homologous recombination deficiency (HRD) benefit more from PARPi treatment. Therefore, ...

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...

Genomic Characteristics of a Rare Pancreatic Cancer Undifferentiated Sarcomatoid Carcinoma Subtype Academic Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers, characterized by early invasion and metastasis. Undifferentiated Sarcomatoid Carcinoma (USC) is a particularly aggressive but rare subtype of PDAC, accounting...

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...

Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...

Reversal of Beige Fat Decline by Estrogen Through NAMPT-Regulated Endoplasmic Reticulum Stress Response Abstract: Brown adipocytes are valued for their potential therapeutic effects against metabolic diseases. However, the metabolic advantages provided by these cells deteriorate with age. Our research shows that treating mice with estrogen (E2), a ...

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...