Microglia Undergo Sex-Dimorphic Transcriptional and Metabolic Rewiring During Aging

The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...

Therapeutic Potential of 2-Bromo-1,4-Naphthoquinone in Multiple Sclerosis

2-Bromo-1,4-naphthoquinone Promotes CD8+ T Cell Expansion and Limits Th1/Th17 Cell Development to Alleviate Experimental Autoimmune Encephalomyelitis Introduction Multiple Sclerosis (MS) is a chronic autoimmune disease that primarily affects the Central Nervous System (CNS), impacting approximately 3 million people worldwide. The onset of MS is ass...

CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis

Protective effects of CCR5-overexpressing mesenchymal stem cells on experimental autoimmune uveitis Background Introduction Uveitis is an inflammatory eye disease that seriously threatens vision and can lead to complications such as cataracts, glaucoma, vitreous opacities, retinal detachment, and abnormal retinal vasculature. This disease is widesp...

The Role of Dysregulated miRNA-140 and miRNA-122 in Alzheimer's Disease

Analysis and Potential Applications of miRNAs Related to Alzheimer’s Disease Background and Research Motivation Alzheimer’s Disease (AD) is a progressively worsening neurodegenerative disorder and the most common form of dementia among the elderly. The pathological features of AD in the brain primarily include senile plaques formed by the accumulat...

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming Academic Background Introduction Diabetes is a chronic metabolic disease affecting millions of people worldwide, characterized by hyperglycemia, or elevated blood glucose levels. For a long time, research has primarily focused on ...

Study on the Effects of Traumatic Brain Injury on Chronic Meningeal CLIP+ B Cells, Neuropathology, and Neurobehavioral Impairment in 5xFAD Mice

Research Report: Long-Term Effects of Class II Invariant Peptide (CLIP) Antagonism on CLIP+ B Cells in the Meninges, Neuropathology, and Neurobehavioral Deficits in 5xFAD Mice Research Background Traumatic brain injury (TBI) is a significant public health problem affecting millions of individuals worldwide each year. More importantly, TBI is a sign...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

Regulation of Neuroinflammation and Demyelination by Cystatin F Following Murine Coronavirus Infection of the Central Nervous System

The Role of Cystatin F in Regulating Neuroinflammation and Demyelination in Spinal Cord Poliovirus Infection Background Knowledge Cystatin F is a secreted lysosomal cysteine protease inhibitor associated with every stage of virus-related neurological diseases, including host defense, demyelination, and myelination. However, research on how Cystatin...

Genome-Wide Loss of Heterozygosity Predicts Aggressive, Treatment-Refractory Behavior in Pituitary Neuroendocrine Tumors

Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...